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Brain & Mental Performance

Focus, memory, mood, and neuroprotection.

Ranked by evidence strength across reported benefits.

Compound#1· strong

Creatine Monohydrate

The most-studied and effective ergogenic aid — replenishes ATP via the phosphocreatine system.

Herb#2· strong

Ashwagandha

Adaptogenic herb that down-regulates HPA-axis output — lowers cortisol, supports T in stressed men.

Vitamin#3· strong

Vitamin D3

Steroid hormone precursor regulating ~5% of the human genome — bone, immune, and hormonal health.

Fatty Acid#4· strong

Omega-3 (EPA/DHA)

Marine long-chain omega-3s — the most-studied anti-inflammatory and cardiovascular nutrient.

Compound#5· strong

Melatonin

Pineal hormone that signals biological night — most effective for circadian-rhythm shifts.

Compound#6· strong

Coffee

Caffeine + polyphenol matrix with strong evidence for mortality and T2D reduction.

Vitamin#7· strong

Vitamin B12

Essential cobalamin for methylation, red blood cell formation, and myelin maintenance.

Amino Acid#8· strong

L-Theanine

Calm focus — alpha-wave amino acid from green tea that takes the edge off caffeine.

Amino Acid#9· strong

N-Acetyl Cysteine (NAC)

Glutathione precursor with mucolytic, hepatoprotective, and psychiatric uses.

Vitamin#10· strong

Vitamin B3 (Niacin)

NAD+ precursor; nicotinic acid form lowers LDL and raises HDL.

Compound#11· strong

Caffeine

Adenosine antagonist with strong evidence for cognitive and physical performance.

Mineral#12· strong

Magnesium Glycinate

Chelated magnesium bound to glycine — best-tolerated form for sleep, calm, and muscle relaxation.

Herb#13· strong

Saffron

Culinary spice with antidepressant effects comparable to SSRIs in mild-moderate depression.

Vitamin#14· strong

Vitamin C

Water-soluble antioxidant, collagen cofactor, and immune supporter.

Vitamin#15· strong

Vitamin B1 (Thiamine)

Cofactor for carbohydrate metabolism and nerve conduction.

Vitamin#16· strong

Vitamin B6 (Pyridoxine)

Cofactor for >100 enzymes including neurotransmitter synthesis.

Vitamin#17· strong

Folate (Vitamin B9)

One-carbon donor essential for DNA synthesis and neural tube development.

Herb#18· strong

Milk Thistle

Hepatoprotective herb with antioxidant and anti-fibrotic effects.

Herb#19· strong

Garlic

Culinary bulb with cardiovascular benefits primarily via allicin and aged-garlic compounds.

Compound#20· strong

Myo-Inositol

Insulin sensitizer used for PCOS and anxiety/OCD support.

Compound#21· strong

CBD (Cannabidiol)

Non-intoxicating cannabinoid studied for anxiety, sleep, and seizures.

Amino Acid#22· strong

Glycine

Inhibitory amino acid that improves sleep quality, glycemic control, and collagen synthesis.

Vitamin#23· strong

Methylfolate (L-5-MTHF)

Bioactive folate that bypasses the MTHFR enzyme — preferred in MTHFR variants and pregnancy.

Compound#24· strong

Creatine Monohydrate

Gold-standard creatine form — the most studied supplement in sports science.

Herb#25· strong

Mucuna Pruriens (Velvet Bean)

Natural L-DOPA source studied for Parkinson's, libido, and fertility.

Nootropic#26· strong

Piracetam (Cognitive)

Original racetam used for cortical excitability disorders.

Compound#27· strong

Nicotinamide Riboside (NR)

NAD+ precursor with bioavailability and longevity research interest.

Compound#28· strong

NMN

NAD+ precursor similar to NR; bioavailability route debated.

Vitamin#29· strong

Methylcobalamin (B12)

Active methyl-form of B12 — directly usable in the methylation cycle.

Vitamin#30· strong

Nicotinamide Riboside (NR)

NAD+ precursor that bypasses the flush — studied for cellular aging.

Herb#31· strong

Kava

Polynesian anxiolytic with strong evidence; rare hepatotoxicity risk.

Herb#32· strong

St. John's Wort

Mild-moderate antidepressant with significant CYP450 drug interactions.

Herb#33· strong

Bacopa Monnieri

Ayurvedic nootropic with strong evidence for memory consolidation over 8–12 weeks.

Compound#34· strong

Alpha-Lipoic Acid

Mitochondrial antioxidant studied for diabetic neuropathy and insulin sensitivity.

Fatty Acid#35· strong

Algal Omega-3 (Vegan EPA/DHA)

Plant-based EPA and DHA from microalgae for vegan diets.

Compound#36· strong

Modafinil (Rx note)

Wakefulness-promoting Rx — listed for reference; not a supplement.

Compound#37· strong

Choline Bitartrate

Affordable choline source — supports phospholipid synthesis and methylation.

Herb#38· strong

Bacopa Monnieri

Ayurvedic nootropic with strong evidence for memory and recall after chronic dosing.

Compound#39· strong

Modafinil (Rx, reference)

Wakefulness-promoting agent — listed for reference only (prescription drug).

Herb#40· strong

St. John's Wort

Hyperforin-containing herb — effective for mild-moderate depression but extensive drug interactions.

Fatty Acid#41· strong

Omega-3 (rTG form)

Re-esterified triglyceride EPA/DHA — ~70% better absorption than ethyl ester form.

Fatty Acid#42· strong

Algal Omega-3 (DHA/EPA)

Plant-source DHA (and some EPA) from cultivated marine algae — vegan alternative to fish oil.

Compound#43· strong

Idebenone

Synthetic CoQ10 analog with better water solubility; used in LHON.

Compound#44· strong

Guanfacine (Ref)

α2A-agonist reference drug for prefrontal focus and ADHD.

Herb#45· strong

Lavender Oil (Silexan)

Oral lavender essential oil with proven anxiolytic effect.

Mineral#46· strong

Selenium-Enriched Yeast

Yeast-bound selenomethionine — form used in major chemoprevention trials.

Fatty Acid#47· strong

EPA-Only Omega-3

Pure EPA reduces residual cardiovascular risk on statins.

Fatty Acid#48· strong

DHA (Prenatal)

Critical fatty acid for fetal brain and retinal development.

Compound#49· strong

ALA (R-isomer)

Natural enantiomer of α-lipoic acid with better bioavailability.

Herb#50· strong

Kava (WS-1490)

Standardized kavalactone extract for anxiety.

Herb#51· strong

Chamomile (GAD)

Matricaria recutita standardized extract for generalized anxiety.

Compound#52· moderate

Glycine + NAC (GlyNAC)

Co-supplementation of glycine and N-acetylcysteine that restores glutathione in older adults and improves multiple hallmarks of aging.

Vitamin#53· moderate

Vitamin K2 (MK-7)

Activates the proteins that direct calcium into bone — not arteries.

Compound#54· moderate

Coenzyme Q10

Mitochondrial electron carrier and lipid-soluble antioxidant.

Amino Acid#55· moderate

L-Carnitine

Shuttles long-chain fatty acids into mitochondria for β-oxidation.

Herb#56· moderate

Rhodiola Rosea

Arctic adaptogen — reduces fatigue and improves mental performance under stress.

Herb#57· moderate

Curcumin

Yellow polyphenol from turmeric — anti-inflammatory and joint-supportive when properly bioavailable.

Amino Acid#58· moderate

Glycine

Inhibitory neurotransmitter that improves sleep quality and supports collagen synthesis.

Vitamin#59· moderate

Vitamin E

Primary lipid-phase antioxidant protecting membrane PUFAs.

Compound#60· moderate

Choline

Essential nutrient for cell membranes, methylation, and acetylcholine synthesis.

Herb#61· moderate

Panax Ginseng

Adaptogenic ginseng studied for fatigue, cognition, and erectile function.

Herb#62· moderate

American Ginseng

Cooler adaptogen with stronger evidence for blood sugar and cold-flu prevention.

Herb#63· moderate

Holy Basil (Tulsi)

Ayurvedic adaptogen with anti-stress, anti-inflammatory, and glycemic effects.

Herb#64· moderate

Mucuna Pruriens

Natural L-DOPA source studied for mood, libido, and Parkinson's.

Herb#65· moderate

Pomegranate

Polyphenol-rich fruit converted by gut microbes to urolithin A (mitochondrial benefit).

Herb#66· moderate

Green Tea (EGCG)

Polyphenol-rich tea; EGCG modestly boosts metabolism and supports cardiovascular health.

Compound#67· moderate

DHEA

Adrenal androgen precursor declining with age; used for adrenal insufficiency and aging.

Compound#68· moderate

Phosphatidylserine (PS)

Phospholipid that supports cognition and may blunt cortisol response to stress.

Compound#69· moderate

Astaxanthin

Algal carotenoid that is the strongest membrane antioxidant; UV and eye protection.

Compound#70· moderate

Alpha-Lipoic Acid (ALA)

Universal antioxidant that's both water and fat soluble — supports glycemic control and nerve health.

Amino Acid#71· moderate

L-Theanine (Sleep)

Tea-derived amino acid that raises alpha brainwaves — relaxation without sedation.

Compound#72· moderate

Phosphatidylserine

Membrane phospholipid — blunts cortisol response to stress and exercise.

Compound#73· moderate

SAMe (S-Adenosyl Methionine)

Universal methyl donor with antidepressant and liver-supportive evidence.

Compound#74· moderate

Ubiquinol (CoQ10)

Reduced active form of CoQ10 — preferred in adults over 40 and those with statin-induced depletion.

Vitamin#75· moderate

Vitamin K2 (MK-7)

Long-half-life K2 — directs calcium to bone and away from arteries.

Compound#76· moderate

Astaxanthin (Eye dose)

Carotenoid that crosses BBB and accumulates in ciliary body.

Herb#77· moderate

Salvia officinalis (Sage)

Culinary sage with cholinergic and anti-hyperhidrosis effects.

Nootropic#78· moderate

Alpha-GPC

Bioavailable choline source studied for cognition and acute power output.

Amino Acid#79· moderate

Taurine

Conditionally essential amino acid involved in bile salt conjugation, osmoregulation, and cardiac function.

Compound#80· moderate

Glutathione

Master intracellular antioxidant; oral bioavailability depends on form.

Compound#81· moderate

TUDCA

Bile acid with hepatoprotective effects and ER stress reduction.

Herb#82· moderate

Passionflower

Mild anxiolytic and sleep aid with GABA-A modulation.

Herb#83· moderate

Ginkgo Biloba

Vasoactive herb studied for cognition in the elderly and tinnitus.

Herb#84· moderate

Gotu Kola

Adaptogen used for cognitive support, anxiety, and wound healing.

Compound#85· moderate

Shilajit

Himalayan mineral exudate rich in fulvic acid, studied for testosterone and fatigue.

Mushroom#86· moderate

Reishi

Adaptogenic mushroom used for immune balance, sleep, and stress.

Compound#87· moderate

Quercetin

Flavonoid with antihistamine and senolytic effects; pairs with bromelain or vitamin C.

Compound#88· moderate

TUDCA (Tauroursodeoxycholic Acid)

Conjugated bile acid — hepatoprotective and ER-stress-reducing.

Compound#89· moderate

Citicoline (CDP-Choline)

Phospholipid precursor with cytidine bonus — supports membranes and dopamine.

Compound#90· moderate

Resveratrol

Polyphenol from grapes — sirtuin activator with mixed human evidence.

Amino Acid#91· moderate

Taurine

Conditionally essential amino acid with cardiovascular, metabolic, and longevity effects.

Herb#92· moderate

Mucuna Pruriens (Fertility)

L-DOPA-containing legume — improves sperm parameters and dopaminergic tone.

Herb#93· moderate

Rhodiola Rosea

Arctic adaptogen for mental fatigue, burnout, and stress resilience.

Herb#94· moderate

Ginkgo Biloba

Vasodilatory leaf extract for cognition and microcirculation.

Herb#95· moderate

Saffron (Crocus sativus)

Crocin-rich spice with antidepressant effects comparable to SSRIs in mild–moderate depression.

Herb#96· moderate

Centella Asiatica (Gotu Kola)

Traditional brain and skin tonic — supports cognition and wound healing.

Mineral#97· moderate

Magnesium L-Threonate

Magnesium bound to L-threonic acid — the only form shown to meaningfully raise brain magnesium.

Vitamin#98· moderate

P-5-P (Pyridoxal-5-Phosphate)

Active coenzyme form of B6 — preferred over pyridoxine HCl for sensitive populations.

Fatty Acid#99· moderate

Krill Oil

Phospholipid-bound EPA/DHA from Antarctic krill — includes astaxanthin antioxidant.

Compound#100· moderate

NMN (Nicotinamide Mononucleotide)

Direct NAD+ precursor — popular longevity supplement with growing human data.

Herb#101· moderate

Kanna (Sceletium)

South African succulent acting as SSRI + PDE4 inhibitor for mood and stress.

Amino Acid#102· moderate

Taurine (High-Dose)

Conditionally essential amino acid with longevity and metabolic effects.

Herb#103· moderate

Passionflower (Anxiety)

Passiflora incarnata for mild GAD and pre-surgical anxiety.

Amino Acid#104· moderate

L-Tyrosine (Dopamine Replenishment)

Catecholamine precursor — replenishes dopamine/norepinephrine pools after stimulant use.

Vitamin#105· moderate

Vitamin B2 (Riboflavin)

FAD/FMN precursor central to redox reactions and migraine prophylaxis.

Mineral#106· moderate

Selenium

Trace mineral essential for glutathione peroxidase and thyroid hormone activation.

Amino Acid#107· moderate

L-Tyrosine

Catecholamine precursor preserving cognition under stress and sleep deprivation.

Amino Acid#108· moderate

L-Tryptophan

Essential amino acid precursor to serotonin and melatonin.

Herb#109· moderate

Chamomile

Gentle anxiolytic and sleep-supportive herb.

Herb#110· moderate

Lemon Balm

Mild anxiolytic with cognitive calming effects via GABA-T inhibition.

Fatty Acid#111· moderate

Krill Oil

Phospholipid-bound omega-3 with astaxanthin; better bioavailability than fish oil per gram.

Nootropic#112· moderate

Piracetam

Original racetam; modulates AMPA receptors and membrane fluidity. Rx in many countries.

Compound#113· moderate

Resveratrol

Polyphenol activating sirtuins; bioavailability and clinical effects modest.

Amino Acid#114· moderate

NAC (Post-Use Recovery)

GSH precursor — supports glutamatergic rebalancing and oxidative stress recovery after stimulant or psychedelic use.

Compound#115· moderate

Alpha-GPC (Cholinergic Recovery)

Choline source — supports acetylcholine after stimulant-driven depletion.

Compound#116· moderate

Urolithin A

Gut-microbial metabolite of ellagitannins — induces mitophagy.

Amino Acid#117· moderate

L-Tyrosine (Thyroid Substrate)

Amino acid substrate paired with iodine to form thyroid hormones.

Herb#118· moderate

Ashwagandha (Cortisol Lowering)

Validated cortisol-lowering adaptogen — ~28% reduction in chronically stressed adults.

Herb#119· moderate

Holy Basil (Tulsi)

Sacred basil adaptogen — anti-stress and mild glucose-lowering effects.

Compound#120· moderate

Huperzine A

Acetylcholinesterase inhibitor from club moss — potent cholinergic enhancer.

Compound#121· moderate

Uridine Monophosphate

Pyrimidine nucleoside — supports phosphatidylcholine synthesis and dopamine receptor density.

Vitamin#122· moderate

Riboflavin-5-Phosphate

Active form of B2 — used directly as FMN without liver conversion.

Vitamin#123· moderate

Benfotiamine

Lipid-soluble thiamine derivative with superior tissue penetration — used in diabetic neuropathy.

Herb#124· moderate

Curcumin Phytosome (Meriva)

Phosphatidylcholine-complexed curcumin — ~29× higher bioavailability than standard extract.

Herb#125· moderate

Sensoril Ashwagandha

Root + leaf extract standardized to ≥10% withanolides — higher potency, more sedating.

Mineral#126· moderate

Selenomethionine

Organic selenium form — preferred for thyroid (Hashimoto's) and antioxidant support.

Nootropic#127· moderate

Sulbutiamine

Lipid-soluble thiamine derivative crossing the BBB for fatigue and focus.

Nootropic#128· moderate

Vinpocetine

Periwinkle alkaloid that increases cerebral blood flow.

Herb#129· moderate

Magnolia Bark

GABAergic anxiolytic bark extract used for sleep and stress.

Compound#130· moderate

Bifidobacterium longum 1714

Psychobiotic strain shown to reduce stress and improve memory.

Compound#131· moderate

Pterostilbene (Extra)

Methylated resveratrol analog with superior bioavailability.

Vitamin#132· moderate

Tocotrienols (Skin/Aging)

Vitamin E isoforms with 40–60× higher antioxidant power than tocopherols.

Herb#133· moderate

Schisandra (Adaptogen)

Berry adaptogen for stress, focus, and liver protection.

Herb#134· moderate

Lemon Balm (Stress)

Melissa officinalis for acute stress and cognitive performance.

Compound#135· moderate

Trans-Resveratrol (Pure)

Purified active isomer of resveratrol.

Compound#136· moderate

Spermidine (Wheat Germ)

Polyamine that induces autophagy and may extend lifespan.

Compound#137· moderate

Urolithin A (Mitopure)

Gut-derived ellagitannin metabolite that induces mitophagy.

Compound#138· moderate

Creatine (Cognitive Dose)

Higher-dose creatine for cognitive performance under stress.

Vitamin#139· moderate

Mixed Tocopherols

Full-spectrum natural vitamin E avoiding α-only supplementation pitfalls.

Nootropic#140· moderate

Citicoline (Cognition)

Intermediate in phosphatidylcholine synthesis; boosts focus.

Compound#141· moderate

Uridine Monophosphate

Pyrimidine that supports synaptic membrane synthesis.

Compound#142· moderate

Phosphatidylcholine (PC)

Major brain and hepatic phospholipid often given for liver support.

Compound#143· moderate

5-HTP (Mood Dose)

Serotonin precursor used for mild depression and migraine.

Amino Acid#144· moderate

L-Tryptophan (Sleep)

Direct serotonin/melatonin precursor for nocturnal use.

Compound#145· moderate

GABA (Pharma-grade)

Fermented GABA with reported peripheral relaxation effects.

Herb#146· moderate

Valerian (Sleep)

Valeriana officinalis root extract for sleep latency.

Herb#147· moderate

Rosemary (Cognitive)

Rosmarinus officinalis for memory and mood via inhalation or oral.

Herb#148· moderate

Yerba Mate (Focus)

Polyphenolic stimulant alternative to coffee for focus.

Herb#149· moderate

Panax Ginseng (Cognitive)

Asian ginseng (G115) studied for mental performance.

Herb#150· moderate

Rhodiola SHR-5 (Fatigue)

Adaptogen for stress-related fatigue and burnout.

Herb#151· moderate

Holy Basil (Tulsi)

Adaptogenic basil used for stress and blood sugar.

Herb#152· moderate

Butterbur

Petasites hybridus extract for migraine prophylaxis and allergic rhinitis.

Herb#153· moderate

Blue Vervain

Verbena hastata for nervous tension and headache.

Herb#154· moderate

California Poppy

Eschscholzia californica for anxiety and insomnia.

Herb#155· moderate

Mulungu

Erythrina mulungu bark for anxiety relief.

Herb#156· moderate

Bacopa CDRI-08

Standardized Bacopa monnieri extract for memory.

Peptide#157· moderate

Epitalon

Tetrapeptide that activates telomerase.

Peptide#158· moderate

MOTS-c

Mitochondrial-derived peptide for metabolic regulation.

Peptide#159· moderate

SS-31 (Elamipretide)

Mitochondrial-targeted peptide for cardiolipin protection.

Peptide#160· moderate

Selank

Russian anxiolytic peptide based on tuftsin.

Peptide#161· moderate

Semax

Russian nootropic ACTH analog for cognitive enhancement.

Compound#162· moderate

Rapamycin

mTOR inhibitor studied for longevity (Rx only).

Compound#163· moderate

Metformin (Longevity Use)

Biguanide diabetes drug studied for healthspan.

Compound#164· moderate

MCT C8 (Caprylic Acid)

Pure C8 medium-chain triglyceride for ketone production.

Herb#165· moderate

Ashwagandha KSM-66

Standardized Withania somnifera root extract for stress.

Herb#166· moderate

Shoden Ashwagandha

35% withanolide glycoside Ashwagandha for sleep.

Herb#167· moderate

Mucuna Pruriens

Velvet bean providing natural L-DOPA.

Compound#168· moderate

MitoQ

Mitochondria-targeted ubiquinone (CoQ10 analog).

Compound#169· moderate

PQQ (Pyrroloquinoline Quinone)

Redox cofactor for mitochondrial biogenesis.

Compound#170· moderate

C60 in Olive Oil

Buckminsterfullerene antioxidant.

Amino Acid#171· moderate

Ergothioneine (Mushroom-Derived)

Natural ergothioneine from oyster mushrooms.

Compound#172· moderate

Hydroxytyrosol

Olive polyphenol for cardiovascular health.

Compound#173· moderate

Bifidobacterium Longum 1714

Psychobiotic for stress and mood.

Compound#174· moderate

L. helveticus R0052

Psychobiotic blend component for mood.

Amino Acid#175· moderate

L-Phenylalanine

Precursor to tyrosine and catecholamines.

Amino Acid#176· moderate

DL-Phenylalanine (DLPA)

Racemic phenylalanine for pain and mood.

Mineral#177· moderate

Selenium (Selenomethionine)

Antioxidant trace element for thyroid.

Herb#178· moderate

Theracurmin

Nano-particle curcumin for bioavailability.

Herb#179· moderate

BCM-95 Curcumin

Curcumin with turmeric oils for absorption.

Compound#180· moderate

Luteolin

Flavone with anti-inflammatory effects.

Compound#181· moderate

Baicalin

Scutellaria baicalensis flavonoid.

Herb#182· moderate

Rhodiola SHR-5

Standardized Rhodiola for fatigue.

Mushroom#183· moderate

Lion's Mane Erinacines

Hericium erinaceus mycelium for NGF.

Mushroom#184· moderate

Lion's Mane Fruiting Body

Hericinones-rich beta-glucan source.

Nootropic#185· moderate

CDP-Choline (Citicoline)

Phospholipid precursor for cognition.

Compound#186· moderate

Soy Lecithin

Phosphatidylcholine source.

Compound#187· moderate

Phosphatidylcholine

Membrane phospholipid for liver.

Compound#188· moderate

Myo-Inositol (High-Dose)

High-dose for psychiatric uses.

Amino Acid#189· moderate

Suntheanine

Pharmaceutical-grade L-theanine.

Amino Acid#190· moderate

PharmaGABA

Naturally fermented GABA.

Compound#191· moderate

Picamilon

Niacin-GABA conjugate.

Nootropic#192· moderate

Aniracetam

Fat-soluble racetam.

Nootropic#193· moderate

Oxiracetam

Racetam for cognition.

Vitamin#194· moderate

Allithiamine

Garlic-derived fat-soluble thiamine.

Vitamin#195· moderate

Folinic Acid (Leucovorin)

Reduced folate form.

Vitamin#196· moderate

Methylcobalamin High-Dose

Active B12 form for neuropathy.

Nootropic#197· moderate

CDP-Choline (Citicoline)-Stroke

Acute stroke neuroprotection.

Nootropic#198· moderate

Noopept (GVS-111)

Russian dipeptide nootropic.

Nootropic#199· moderate

DMAE (Dimethylaminoethanol)

Choline analog for cognition.

Nootropic#200· moderate

Pyritinol

Pyridoxine derivative for cognition.

Compound#201· moderate

Galantamine (Plant-Derived)

Snowdrop alkaloid AChE inhibitor.

Herb#202· moderate

Ginkgo Biloba EGb 761

Standardized Ginkgo for cognition.

Vitamin#203· moderate

Biotin (High-Dose)

High-dose for MS and hair.

Compound#204· moderate

Enzogenol

New Zealand pine bark extract.

Compound#205· moderate

Pycnogenol (Pine Bark)

French maritime pine bark for circulation.

Compound#206· moderate

Trans-Resveratrol

Active form of resveratrol.

Compound#207· moderate

Micronized Resveratrol

Improved bioavailability resveratrol.

Compound#208· moderate

Punicalagin

Major pomegranate ellagitannin.

Compound#209· moderate

Ellagic Acid

Ellagitannin hydrolysis product.

Compound#210· moderate

GOS (Galactooligosaccharides)

Galactose-based prebiotic.

Compound#211· moderate

6-Shogaol (Ginger)

Bioactive ginger compound.

Herb#212· moderate

Holy Basil (Tulsi)

Ocimum sanctum adaptogen.

Herb#213· moderate

Ocimum Tenuiflorum (OciBest)

Standardized Holy Basil for stress.

Herb#214· moderate

Turmeric Essential Oil

Ar-turmerone for brain regeneration.

Herb#215· moderate

Longvida Curcumin

SLCP curcumin for brain bioavailability.

Herb#216· moderate

Lemon Balm Melissa Officinalis (Bluenesse)

Standardized Melissa for cognition.

Herb#217· moderate

Saffron Affron

Standardized saffron for mood.

Herb#218· moderate

Saffron Satiereal

Saffron for appetite and snacking.

Compound#219· moderate

Honokiol

Active magnolia compound.

Compound#220· moderate

Magnolol

Active magnolia biphenol.

Compound#221· moderate

Oleocanthal

EVOO ibuprofen-like compound.

Fatty Acid#222· moderate

EPA-Dominant Fish Oil

Concentrated EPA for inflammation.

Fatty Acid#223· moderate

DHA-Dominant Fish Oil

High-DHA for brain health.

Fatty Acid#224· moderate

Algae Omega-3

Vegan EPA/DHA source.

Fatty Acid#225· moderate

Salmon Roe Phospholipids

Phospholipid omega-3s from salmon eggs.

Mushroom#226· limited

Lion's Mane

Edible medicinal mushroom that upregulates NGF and BDNF — studied for nerve growth and cognition.

Amino Acid#227· limited

5-HTP

Direct serotonin precursor with mood and sleep applications.

Compound#228· limited

Fisetin

Flavonoid studied as senolytic — clearing senescent cells in animal models.

Compound#229· limited

Quercetin

Flavonoid with antihistamine, anti-viral, and senolytic activity.

Nootropic#230· limited

Noopept

Synthetic peptide with NGF/BDNF-raising activity at very low doses.

Vitamin#231· limited

Tocotrienols (Vitamin E)

Unsaturated vitamin E family — superior antioxidant capacity vs alpha-tocopherol.

Herb#232· limited

Cistanche Tubulosa

Desert plant tonic for libido and cognition.

Mineral#233· limited

Lithium Orotate (low-dose)

Low-dose lithium salt studied for mood stability and neuroprotection.

Amino Acid#234· limited

GABA

Primary inhibitory neurotransmitter; oral supplementation has limited CNS penetration.

Herb#235· limited

Valerian Root

Sedative herb traditionally used for sleep onset and mild anxiety.

Mushroom#236· limited

Chaga

Birch-tree mushroom rich in melanin, betulin, and antioxidants.

Compound#237· limited

Pregnenolone

Master steroid precursor; small doses studied for cognition and PTSD.

Nootropic#238· limited

Noopept

Synthetic dipeptide (peptide-like) studied for cognition and neuroprotection; not FDA approved.

Compound#239· limited

PQQ

Cofactor stimulating mitochondrial biogenesis (PGC-1α).

Compound#240· limited

Pterostilbene

Bioavailable resveratrol analog with longer half-life.

Compound#241· limited

Spermidine

Polyamine inducing autophagy; epidemiologic association with longevity.

Nootropic#242· limited

Phenibut (caution)

GABA-B agonist with high abuse and dependence potential; restricted in many countries.

Herb#243· limited

Kratom (caution)

Atypical opioid herb with stimulant low-dose and sedating high-dose effects; addiction risk.

Mineral#244· limited

Magnesium L-Threonate

Mg form designed for brain penetration; studied for cognition and sleep.

Amino Acid#245· limited

ALCAR + ALA (Mitochondrial Protection)

Mitochondrial antioxidant stack — popularized as harm-reduction adjunct for MDMA neuroprotection.

Compound#246· limited

EGCG (Green Tea Catechin)

Potent CYP/COMT-modulating antioxidant — popularized in MDMA harm-reduction stacks.

Mushroom#247· limited

Lion's Mane (Neuroregeneration)

NGF-upregulating mushroom — included in post-use stacks for neurotrophic support.

Compound#248· limited

Pterostilbene

Methylated analog of resveratrol — better bioavailability and longer half-life.

Compound#249· limited

Spermidine

Polyamine that induces autophagy — emerging longevity supplement.

Compound#250· limited

Apigenin

Chamomile/parsley flavonoid — GABA-A modulator and CD38 inhibitor for sleep and NAD+.

Herb#251· limited

Valerian Root

GABAergic sedative herb — modest sleep onset benefit.

Herb#252· limited

Passionflower

Anxiolytic herb shown comparable to oxazepam for generalized anxiety.

Herb#253· limited

Lemon Balm (Melissa)

Anxiolytic mint-family herb with GABA-T inhibition.

Amino Acid#254· limited

5-HTP (Sleep Use)

Serotonin → melatonin precursor — supports sleep onset and depth.

Nootropic#255· limited

Pramiracetam

Racetam family — increases high-affinity choline uptake.

Nootropic#256· limited

Phenylpiracetam

Racetam + phenethylamine moiety — stimulant-like nootropic with rapid tolerance.

Compound#257· limited

Liposomal Glutathione

Phospholipid-encapsulated GSH — protects from gut breakdown for systemic delivery.

Compound#258· limited

S-Acetyl Glutathione

Acetylated GSH — stable through the gut and converted intracellularly to glutathione.

Compound#259· limited

Agmatine Sulfate

Arginine metabolite with NMDA modulation and analgesic properties.

Nootropic#260· limited

9-Me-BC

β-carboline alkaloid that upregulates dopamine neurons in animal models.

Nootropic#261· limited

Centrophenoxine

Cholinergic precursor that reduces lipofuscin accumulation in neurons.

Nootropic#262· limited

Phenylpiracetam Hydrazide

Hydrazide analog of phenylpiracetam reported to support memory and locomotion.

Nootropic#263· limited

Coluracetam

Racetam acting on high-affinity choline uptake; studied for depression/anxiety.

Herb#264· limited

Chinese Skullcap

Flavonoid-rich root used for anxiety and inflammation.

Herb#265· limited

California Poppy

Mild sedative with anxiolytic and analgesic activity.

Herb#266· limited

Ziziphus (Jujube Seed)

Traditional Chinese seed extract for insomnia and anxiety.

Peptide#267· limited

Thymulin (Reference)

Zinc-dependent thymic peptide that matures T-cells.

Compound#268· limited

Alpha-Ketoglutarate (AKG)

TCA-cycle intermediate studied for healthspan and frailty.

Compound#269· limited

Fisetin (Senolytic)

Polyphenol senolytic with neuroprotective and anti-inflammatory effects.

Compound#270· limited

Quercetin + Dasatinib (D+Q)

Reference senolytic combination cycled to clear senescent cells.

Amino Acid#271· limited

L-Carnosine

Dipeptide that buffers protons and reduces advanced glycation end-products.

Compound#272· limited

Ergothioneine (Extra)

Unique thiol antioxidant concentrated in mitochondria via OCTN1.

Nootropic#273· limited

Noopept (High-Dose)

Russian dipeptide claimed to enhance BDNF and NGF.

Mineral#274· limited

Magnesium Acetyl-Taurate

Brain-penetrant Mg form combined with taurate for mood.

Amino Acid#275· limited

DL-Phenylalanine

Catecholamine precursor with mild analgesic properties.

Compound#276· limited

Phenibut (Ref)

GABA-B agonist developed in the USSR for anxiety (caution).

Amino Acid#277· anecdotal

5-HTP (Post-MDMA Replenishment)

Serotonin precursor — used post-MDMA to support depleted 5-HT stores. Never combine same-day.