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evidence · mechanism · dose
Supplements/Herb

Chamomile (GAD)

Matricaria recutita standardized extract for generalized anxiety.

Mood & AnxietySleep & Recovery

Overview

Matricaria recutita standardized extract for generalized anxiety.

Natural sources
    Common forms

      Forms & variants of Chamomile

      Different chemical forms of Chamomile behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Chamomile

      Gentle anxiolytic and sleep-supportive herb.

      Mechanism of action

      Apigenin partial agonism at GABA-A benzodiazepine site.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces GAD severity over 8 weeks

        Strong evidence

        Potential side effects

        Common
        • · GI upset
        Rare
        • · Allergic reaction (Asteraceae)
        Serious

          Drug interactions

          No notable interactions reported.

          Safety & non-supplemental interactions

          Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

          Avoid if you are
          • ·Pregnant or breastfeeding (insufficient safety data)
          • ·Children under 18 (unless directed by a clinician)
          Avoid / monitor with these medications
          • ·Alcohol, benzodiazepines, opioids, sedating antihistamines (additive CNS depression)

          Supplement interactions

          Pairs well with

          None listed.

          Avoid combining with

          No specific avoidances listed.

          Dosing & bioavailability

          Typical dose
          500–1500 mg standardized (1.2% apigenin)
          With food?
          With food

          Where to buy

          Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

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          Thorne
          Practitioner-grade · NSF tested

          Scientific evidence (8)

          RCTJ Clin Psychopharmacol · 2009

          Chamomile for GAD

          Amsterdam JD, et al.

          8-week DB-RCT in 57 GAD patients.

          Key findings

          Significantly reduced HAM-A scores vs placebo.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Chamomile (GAD) — Reduces GAD severity over 8 weeks

          Live PubMed search

          Live results for "Chamomile (GAD) Reduces GAD severity over 8 weeks" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Chamomile (GAD) and "Reduces GAD severity over 8 weeks". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Chamomile (GAD) — randomized controlled trial

          Live PubMed search

          Live results for "Chamomile (GAD) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Chamomile (GAD) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Chamomile (GAD) — meta-analysis

          Live PubMed search

          Live results for "Chamomile (GAD) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Chamomile (GAD) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Chamomile (GAD) — pharmacokinetics

          Live PubMed search

          Live results for "Chamomile (GAD) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Chamomile (GAD) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Chamomile (GAD) — safety adverse events

          Live PubMed search

          Live results for "Chamomile (GAD) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Chamomile (GAD) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Chamomile (GAD) — dose response

          Live PubMed search

          Live results for "Chamomile (GAD) dose response" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Chamomile (GAD) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewGoogle Scholar · 1970

          Google Scholar: Chamomile (GAD) — clinical evidence

          Live Scholar search

          Cross-database citation index for Chamomile (GAD) as it relates to "clinical evidence".

          Key findings

          Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

          Open study
          Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.