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Supplements/Herb

Chamomile

aka Matricaria recutita

Gentle anxiolytic and sleep-supportive herb.

Sleep & RecoveryMood & AnxietyGut Health

Overview

Gentle anxiolytic and sleep-supportive herb.

Natural sources
  • Matricaria recutita flower
Common forms
  • Tea
  • Standardized extract (apigenin)

Forms & variants of Chamomile

Different chemical forms of Chamomile behave differently. Browse each form's mechanism, bioavailability, and best-use context.

GAD dose
Chamomile (GAD)

Matricaria recutita standardized extract for generalized anxiety.

Mechanism of action

Apigenin binds benzodiazepine site of GABA-A receptor.

Pathways
  • · GABA-A modulation

Effects on the body

Decreases
Anxiety

Organ system effects

Brain & CNS

Reduces GAD symptoms in long-term trials.

Evidence-based benefits

Reduces GAD symptoms (long-term RCTs)

Moderate evidence

Potential side effects

Common
    Rare
    • · Allergy (Asteraceae family)
    Serious
    • · Anaphylaxis (rare)

    Drug interactions

    Warfarin
    Coumarins — mild interaction.
    minor

    Safety & non-supplemental interactions

    Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

    Avoid if you are
    • ·Pregnant or breastfeeding (insufficient safety data)
    • ·Children under 18 (unless directed by a clinician)
    Avoid / monitor with these medications
    • ·Alcohol, benzodiazepines, opioids, sedating antihistamines (additive CNS depression)

    Supplement interactions

    Pairs well with

    None listed.

    Avoid combining with

    No specific avoidances listed.

    Dosing & bioavailability

    Typical dose
    220–1100 mg standardized; or 2–3 cups tea

    Where to buy

    Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

    Herb
    Chamomile
    Amazon
    Wide selection · fast shipping
    Herb
    Chamomile
    iHerb
    Global delivery · curated brands
    Herb
    Chamomile
    Thorne
    Practitioner-grade · NSF tested

    Scientific evidence (8)

    Systematic reviewExamine.com Supplement Database · 2023

    Chamomile: pharmacology, clinical evidence, and safety — narrative review

    Examine.com Research Team

    Curated narrative review of human and preclinical evidence for Chamomile, including mechanism, typical dosing, and safety considerations.

    Key findings

    Best-supported outcome: Reduces GAD symptoms (long-term RCTs) (evidence: moderate). Additional outcomes and limitations summarized in the full profile.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Chamomile — Reduces GAD symptoms

    Live PubMed search

    Live results for "Chamomile Reduces GAD symptoms" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Chamomile and "Reduces GAD symptoms". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Chamomile — randomized controlled trial

    Live PubMed search

    Live results for "Chamomile randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Chamomile and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Chamomile — meta-analysis

    Live PubMed search

    Live results for "Chamomile meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Chamomile and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Chamomile — pharmacokinetics

    Live PubMed search

    Live results for "Chamomile pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Chamomile and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Chamomile — safety adverse events

    Live PubMed search

    Live results for "Chamomile safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Chamomile and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Chamomile — dose response

    Live PubMed search

    Live results for "Chamomile dose response" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Chamomile and "dose response". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewGoogle Scholar · 1970

    Google Scholar: Chamomile — clinical evidence

    Live Scholar search

    Cross-database citation index for Chamomile as it relates to "clinical evidence".

    Key findings

    Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

    Open study
    Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.