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Gut Health

Microbiome, barrier integrity, and motility.

Ranked by evidence strength across reported benefits.

Herb#1· strong

Ginger

Culinary rhizome with strong antiemetic and anti-inflammatory effects.

Compound#2· strong

Psyllium Husk

Soluble fiber with strong evidence for cholesterol reduction and bowel regularity.

Compound#3· strong

Psyllium Husk

Viscous soluble fiber — lowers cholesterol, glucose, and supports regularity.

Mineral#4· strong

Magnesium Oxide

Cheapest magnesium salt — poor absorption (~4%) but useful as a laxative or antacid.

Herb#5· strong

Boswellia

Anti-inflammatory resin used for osteoarthritis and IBD.

Compound#6· strong

Lactobacillus Probiotics

Lactic acid bacteria supporting gut barrier, immunity, and women's urogenital health.

Compound#7· strong

Multi-Strain Probiotic

Live bacterial supplement — strain-specific effects on digestion, immunity, and mood.

Compound#8· strong

Saccharomyces Boulardii

Probiotic yeast — strong evidence for C. difficile and traveler's diarrhea prevention.

Mineral#9· strong

Magnesium Citrate

Highly bioavailable magnesium with a mild osmotic laxative effect — useful for constipation and repletion.

Mushroom#10· strong

Turkey Tail

Beta-glucan-rich mushroom used as immune adjunct in cancer (PSK approved in Japan).

Compound#11· strong

Saccharomyces Boulardii

Beneficial yeast used to prevent and treat several types of diarrhea.

Compound#12· strong

Prebiotics (Inulin, FOS, GOS)

Fermentable fibers feeding beneficial gut bacteria.

Compound#13· strong

Digestive Enzymes

Supplemental enzymes for pancreatic insufficiency or mild bloating.

Herb#14· strong

Peppermint Oil

Enteric-coated peppermint oil is a first-line antispasmodic for IBS.

Herb#15· strong

Ginger Root (Zingiber officinale)

Anti-nausea root — useful for hangover nausea and acid reflux after drinking.

Compound#16· strong

Lactobacillus Rhamnosus GG

Most-studied single strain — atopy, pediatric diarrhea, and antibiotic recovery.

Compound#17· strong

Inulin (Prebiotic Fiber)

Fructan prebiotic — selectively feeds bifidobacteria.

Herb#18· strong

Enteric-Coated Peppermint Oil

Antispasmodic for IBS — strong evidence in enteric-coated form.

Compound#19· moderate

Berberine

Plant alkaloid that activates AMPK — metformin-like effects on glucose and lipids.

Amino Acid#20· moderate

L-Glutamine

Most abundant amino acid; primary fuel for enterocytes and immune cells.

Herb#21· moderate

Licorice Root

Adrenal-supporting herb; chronic high-dose causes pseudo-aldosteronism.

Compound#22· moderate

Bromelain

Pineapple proteolytic enzyme with anti-inflammatory and fibrinolytic effects.

Compound#23· moderate

Bovine Colostrum

First milk rich in IgG, lactoferrin, and growth factors for immune and gut support.

Compound#24· moderate

Lactoferrin

Iron-binding protein with antimicrobial and immunomodulating effects.

Herb#25· moderate

Chamomile

Gentle anxiolytic and sleep-supportive herb.

Compound#26· moderate

Bifidobacterium Probiotics

Dominant probiotic genus in the colon; supports immune and gut barrier.

Herb#27· moderate

DGL (Deglycyrrhizinated Licorice)

Licorice with glycyrrhizin removed; soothes GI mucosa without BP effect.

Herb#28· moderate

Artichoke Leaf

Cholagogue herb improving dyspepsia and modestly reducing cholesterol.

Amino Acid#29· moderate

L-Glutamine (Gut Barrier)

Preferred fuel for enterocytes — supports intestinal barrier integrity.

Compound#30· limited

Betaine HCl

Stomach acid supplement used for hypochlorhydria; controversial.

Herb#31· limited

Slippery Elm

Demulcent herb used for GERD, esophagitis, and IBS.

Peptide#32· limited

BPC-157

Research peptide derived from gastric protein, studied for tendon and gut healing.

Herb#33· limited

DGL (Deglycyrrhizinated Licorice)

Mucilaginous form of licorice with glycyrrhizin removed — soothes GI without raising BP.

Herb#34· limited

Oil of Oregano

Carvacrol-rich essential oil with broad antimicrobial activity (in vitro).