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evidence · mechanism · dose
Supplements/Compound

Saccharomyces Boulardii

Beneficial yeast used to prevent and treat several types of diarrhea.

Gut HealthImmune Function

Overview

Beneficial yeast used to prevent and treat several types of diarrhea.

Natural sources
  • Lychee fruit (originally)
Common forms
  • Lyophilized S. boulardii

Mechanism of action

Yeast competes with pathogens, secretes proteases inactivating C. diff toxins.

Pathways
  • · Pathogen competition
  • · Toxin neutralization

Effects on the body

Decreases
C. difficile recurrence
Decreases
Traveler's diarrhea

Organ system effects

Digestive / Gut

Reduces C. diff recurrence.

Evidence-based benefits

Reduces antibiotic-associated diarrhea & C. diff

Strong evidence

Potential side effects

Common
  • · Bloating
Rare
    Serious
    • · Fungemia in immunocompromised / central line

    Drug interactions

    Antifungals
    Antagonistic.
    moderate

    Safety & non-supplemental interactions

    Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

    Avoid with these conditions
    • ·Autoimmune disease (theoretical immune activation)
    Avoid / monitor with these medications
    • ·Immunosuppressants

    Supplement interactions

    Pairs well with

    None listed.

    Avoid combining with
    • Immunocompromised state
      Fungemia risk.
    • Central line in place
      Bloodstream invasion.

    Dosing & bioavailability

    Typical dose
    250–500 mg × 2/d (5 billion CFU)

    Where to buy

    Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

    Compound
    Saccharomyce…
    Amazon
    Wide selection · fast shipping
    Compound
    Saccharomyce…
    iHerb
    Global delivery · curated brands
    Compound
    Saccharomyce…
    Thorne
    Practitioner-grade · NSF tested

    Scientific evidence (8)

    Meta-analysisWorld J Gastroenterol · 2010

    Saccharomyces boulardii for antibiotic-associated diarrhea

    McFarland LV

    Meta-analysis of S. boulardii RCTs.

    Key findings

    Effective in prevention of AAD and recurrent C. difficile.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Saccharomyces Boulardii — Reduces antibiotic-associated diarrhea & C. diff

    Live PubMed search

    Live results for "Saccharomyces Boulardii Reduces antibiotic-associated diarrhea & C. diff" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Saccharomyces Boulardii and "Reduces antibiotic-associated diarrhea & C. diff". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Saccharomyces Boulardii — randomized controlled trial

    Live PubMed search

    Live results for "Saccharomyces Boulardii randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Saccharomyces Boulardii and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Saccharomyces Boulardii — meta-analysis

    Live PubMed search

    Live results for "Saccharomyces Boulardii meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Saccharomyces Boulardii and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Saccharomyces Boulardii — pharmacokinetics

    Live PubMed search

    Live results for "Saccharomyces Boulardii pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Saccharomyces Boulardii and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Saccharomyces Boulardii — safety adverse events

    Live PubMed search

    Live results for "Saccharomyces Boulardii safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Saccharomyces Boulardii and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Saccharomyces Boulardii — dose response

    Live PubMed search

    Live results for "Saccharomyces Boulardii dose response" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Saccharomyces Boulardii and "dose response". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewGoogle Scholar · 1970

    Google Scholar: Saccharomyces Boulardii — clinical evidence

    Live Scholar search

    Cross-database citation index for Saccharomyces Boulardii as it relates to "clinical evidence".

    Key findings

    Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

    Open study
    Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.