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SUPPLEMENT_SCHOLAR
evidence · mechanism · dose
Supplements/Compound

Lactoferrin

Iron-binding protein with antimicrobial and immunomodulating effects.

Immune FunctionGut Health

Overview

Iron-binding protein with antimicrobial and immunomodulating effects.

Natural sources
  • Whey
  • Colostrum
Common forms
  • Apolactoferrin

Mechanism of action

Sequesters iron from pathogens; modulates immune signaling.

Pathways
  • · Iron sequestration
  • · Immune modulation

Effects on the body

Supports
Antimicrobial activity

Organ system effects

Digestive / Gut

Reduces H. pylori load.

Evidence-based benefits

Reduces H. pylori in triple therapy

Moderate evidence

Reduces sepsis in preterm infants

Moderate evidence

Potential side effects

Common
    Rare
      Serious

        Drug interactions

        No notable interactions reported.

        Safety & non-supplemental interactions

        Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

        Avoid with these conditions
        • ·Autoimmune disease (theoretical immune activation)
        Avoid / monitor with these medications
        • ·Immunosuppressants

        Supplement interactions

        Pairs well with

        None listed.

        Avoid combining with

        No specific avoidances listed.

        Dosing & bioavailability

        Typical dose
        200–600 mg/d

        Where to buy

        Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

        Compound
        Lactoferrin
        Amazon
        Wide selection · fast shipping
        Compound
        Lactoferrin
        iHerb
        Global delivery · curated brands
        Compound
        Lactoferrin
        Thorne
        Practitioner-grade · NSF tested

        Scientific evidence (9)

        RCTBiochem Cell Biol · 2014

        Bovine lactoferrin for iron deficiency anemia in pregnancy

        Paesano R, et al.

        RCT comparing oral lactoferrin to ferrous sulfate.

        Key findings

        Comparable hemoglobin response with fewer GI side effects.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Lactoferrin — Reduces H. pylori in triple therapy

        Live PubMed search

        Live results for "Lactoferrin Reduces H. pylori in triple therapy" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Lactoferrin and "Reduces H. pylori in triple therapy". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Lactoferrin — Reduces sepsis in preterm infants

        Live PubMed search

        Live results for "Lactoferrin Reduces sepsis in preterm infants" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Lactoferrin and "Reduces sepsis in preterm infants". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Lactoferrin — randomized controlled trial

        Live PubMed search

        Live results for "Lactoferrin randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Lactoferrin and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Lactoferrin — meta-analysis

        Live PubMed search

        Live results for "Lactoferrin meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Lactoferrin and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Lactoferrin — pharmacokinetics

        Live PubMed search

        Live results for "Lactoferrin pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Lactoferrin and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Lactoferrin — safety adverse events

        Live PubMed search

        Live results for "Lactoferrin safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Lactoferrin and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Lactoferrin — dose response

        Live PubMed search

        Live results for "Lactoferrin dose response" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Lactoferrin and "dose response". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewGoogle Scholar · 1970

        Google Scholar: Lactoferrin — clinical evidence

        Live Scholar search

        Cross-database citation index for Lactoferrin as it relates to "clinical evidence".

        Key findings

        Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

        Open study
        Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.