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evidence · mechanism · dose
Supplements/Peptide

BPC-157

Research peptide derived from gastric protein, studied for tendon and gut healing.

Recovery OptimizationJoint & Connective TissueGut Health

Overview

Research peptide derived from gastric protein, studied for tendon and gut healing.

Natural sources
  • Synthetic peptide
Common forms
  • Injectable
  • Oral (BPC-157 arginate)

Mechanism of action

Promotes angiogenesis via VEGF and modulates nitric oxide.

Pathways
  • · VEGF angiogenesis
  • · NO signaling

Effects on the body

Supports
Tendon/ligament healing (animal)
Supports
Gut healing (animal)

Organ system effects

Joints

Animal evidence of tendon healing.

Digestive / Gut

Animal evidence of gastric healing.

Evidence-based benefits

Robust animal data; minimal human RCTs

Limited evidence

Potential side effects

Common
    Rare
      Serious
      • · Unregulated; purity & contamination concerns

      Drug interactions

      No notable interactions reported.

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid if you are
      • ·Pregnant or breastfeeding (insufficient safety data)
      • ·Children under 18 (unless directed by a clinician)
      Other notes
      • ·Most research peptides are not FDA-approved for human use outside investigational protocols.

      Supplement interactions

      Pairs well with

      None listed.

      Avoid combining with
      • Pregnancy / unknown safety
        No human safety data.

      Dosing & bioavailability

      Typical dose
      Investigational; no validated human dosing

      Where to buy

      Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Peptide
      BPC-157
      Amazon
      Wide selection · fast shipping
      Peptide
      BPC-157
      iHerb
      Global delivery · curated brands
      Peptide
      BPC-157
      Thorne
      Practitioner-grade · NSF tested

      Scientific evidence (8)

      AnimalJ Orthop Res · 2006

      BPC 157 and tendon-to-bone healing in rats

      Krivic A, et al.

      Rodent study of BPC 157 on tendon healing.

      Key findings

      Accelerated healing; no controlled human trials.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: BPC-157 — Robust animal data; minimal human RCTs

      Live PubMed search

      Live results for "BPC-157 Robust animal data; minimal human RCTs" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching BPC-157 and "Robust animal data; minimal human RCTs". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: BPC-157 — randomized controlled trial

      Live PubMed search

      Live results for "BPC-157 randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching BPC-157 and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: BPC-157 — meta-analysis

      Live PubMed search

      Live results for "BPC-157 meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching BPC-157 and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: BPC-157 — pharmacokinetics

      Live PubMed search

      Live results for "BPC-157 pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching BPC-157 and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: BPC-157 — safety adverse events

      Live PubMed search

      Live results for "BPC-157 safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching BPC-157 and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: BPC-157 — dose response

      Live PubMed search

      Live results for "BPC-157 dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching BPC-157 and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: BPC-157 — clinical evidence

      Live Scholar search

      Cross-database citation index for BPC-157 as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.