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evidence · mechanism · dose
Supplements/Herb

DGL (Deglycyrrhizinated Licorice)

aka DGL

Licorice with glycyrrhizin removed; soothes GI mucosa without BP effect.

Gut Health

Overview

Licorice with glycyrrhizin removed; soothes GI mucosa without BP effect.

Natural sources
  • Glycyrrhiza glabra (processed)
Common forms
  • Chewable DGL tablets

Mechanism of action

Increases mucin secretion and epidermal growth factor in gastric mucosa.

Pathways
  • · Mucin secretion ↑

Effects on the body

Supports
Gastric mucosal protection

Organ system effects

Digestive / Gut

Heals NSAID gastritis and aphthous ulcers.

Evidence-based benefits

Heals gastric ulcers and reduces NSAID gastritis

Moderate evidence

Potential side effects

Common
    Rare
      Serious

        Drug interactions

        No notable interactions reported.

        Safety & non-supplemental interactions

        Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

        Avoid if you are
        • ·Pregnant or breastfeeding (insufficient safety data)
        • ·Children under 18 (unless directed by a clinician)

        Supplement interactions

        Pairs well with

        None listed.

        Avoid combining with

        No specific avoidances listed.

        Dosing & bioavailability

        Typical dose
        380–760 mg chewed before meals

        Where to buy

        Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

        Herb
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        iHerb
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        Thorne
        Practitioner-grade · NSF tested

        Scientific evidence (8)

        RCTEvid Based Complement Alternat Med · 2012

        DGL for functional dyspepsia

        Raveendra KR, et al.

        30-day RCT of DGL 150 mg twice daily.

        Key findings

        Significant symptom improvement vs placebo.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: DGL (Deglycyrrhizinated Licorice) — Heals gastric ulcers and reduces NSAID gastritis

        Live PubMed search

        Live results for "DGL (Deglycyrrhizinated Licorice) Heals gastric ulcers and reduces NSAID gastritis" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching DGL (Deglycyrrhizinated Licorice) and "Heals gastric ulcers and reduces NSAID gastritis". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: DGL (Deglycyrrhizinated Licorice) — randomized controlled trial

        Live PubMed search

        Live results for "DGL (Deglycyrrhizinated Licorice) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching DGL (Deglycyrrhizinated Licorice) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: DGL (Deglycyrrhizinated Licorice) — meta-analysis

        Live PubMed search

        Live results for "DGL (Deglycyrrhizinated Licorice) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching DGL (Deglycyrrhizinated Licorice) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: DGL (Deglycyrrhizinated Licorice) — pharmacokinetics

        Live PubMed search

        Live results for "DGL (Deglycyrrhizinated Licorice) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching DGL (Deglycyrrhizinated Licorice) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: DGL (Deglycyrrhizinated Licorice) — safety adverse events

        Live PubMed search

        Live results for "DGL (Deglycyrrhizinated Licorice) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching DGL (Deglycyrrhizinated Licorice) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: DGL (Deglycyrrhizinated Licorice) — dose response

        Live PubMed search

        Live results for "DGL (Deglycyrrhizinated Licorice) dose response" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching DGL (Deglycyrrhizinated Licorice) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewGoogle Scholar · 1970

        Google Scholar: DGL (Deglycyrrhizinated Licorice) — clinical evidence

        Live Scholar search

        Cross-database citation index for DGL (Deglycyrrhizinated Licorice) as it relates to "clinical evidence".

        Key findings

        Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

        Open study
        Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.