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Slippery Elm

aka Ulmus rubra

Demulcent herb used for GERD, esophagitis, and IBS.

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Overview

Demulcent herb used for GERD, esophagitis, and IBS.

Natural sources
  • Ulmus rubra inner bark
Common forms
  • Powder
  • Lozenge

Mechanism of action

Mucilage coats and soothes GI mucosa.

Pathways
  • · Mucosal coating

Effects on the body

Supports
GI mucosal coating

Organ system effects

Digestive / Gut

Soothes irritated mucosa.

Evidence-based benefits

Symptomatic relief in GERD / IBS (small studies)

Limited evidence

Potential side effects

Common
  • · Slippery Elm is generally well-tolerated at evidence-based doses
  • · Mild GI discomfort (nausea, loose stools, or bloating) possible at higher intakes
  • · Headache or transient fatigue reported by a small fraction of users
Rare
  • · Allergic or hypersensitivity reaction (rash, itching, swelling)
  • · Sleep disturbance if taken late in the day
Serious
  • · Discontinue and seek medical advice if symptoms are severe, persistent, or include difficulty breathing

Drug interactions

Most oral medications
Reduces absorption — separate 2 h.
moderate

Safety & non-supplemental interactions

Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

Avoid if you are
  • ·Pregnant or breastfeeding (insufficient safety data)
  • ·Children under 18 (unless directed by a clinician)

Supplement interactions

Pairs well with
  • A high-quality multivitamin
    Covers micronutrient cofactors that support most supplement pathways.
  • Omega-3 (EPA/DHA)
    Foundational anti-inflammatory support that complements most regimens.
Avoid combining with

No specific avoidances listed.

Dosing & bioavailability

Typical dose
400–500 mg × 3/d
Best form
Most evidence is based on the powder form.
Timing
Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
With food?
Either with or without food.

Where to buy

Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

Scientific evidence8Show studies
RCTJ Altern Complement Med · 2010

Herbal formulas containing slippery elm in IBS

Hawrelak JA, Myers SP

Pilot RCT of slippery elm–based blend in IBS.

Key findings

Improved bowel habit and reduced straining.

Open study
Systematic reviewPubMed (NLM) · 1970

PubMed: Slippery Elm — Symptomatic relief in GERD / IBS

Live PubMed search

Live results for "Slippery Elm Symptomatic relief in GERD / IBS" across the PubMed/MEDLINE peer-reviewed index.

Key findings

Opens current human and preclinical literature matching Slippery Elm and "Symptomatic relief in GERD / IBS". Filter by RCT, meta-analysis, or year on the results page.

Open study
Systematic reviewPubMed (NLM) · 1970

PubMed: Slippery Elm — randomized controlled trial

Live PubMed search

Live results for "Slippery Elm randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

Key findings

Opens current human and preclinical literature matching Slippery Elm and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

Open study
Systematic reviewPubMed (NLM) · 1970

PubMed: Slippery Elm — meta-analysis

Live PubMed search

Live results for "Slippery Elm meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

Key findings

Opens current human and preclinical literature matching Slippery Elm and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Open study
Systematic reviewPubMed (NLM) · 1970

PubMed: Slippery Elm — pharmacokinetics

Live PubMed search

Live results for "Slippery Elm pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

Key findings

Opens current human and preclinical literature matching Slippery Elm and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

Open study
Systematic reviewPubMed (NLM) · 1970

PubMed: Slippery Elm — safety adverse events

Live PubMed search

Live results for "Slippery Elm safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

Key findings

Opens current human and preclinical literature matching Slippery Elm and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

Open study
Systematic reviewPubMed (NLM) · 1970

PubMed: Slippery Elm — dose response

Live PubMed search

Live results for "Slippery Elm dose response" across the PubMed/MEDLINE peer-reviewed index.

Key findings

Opens current human and preclinical literature matching Slippery Elm and "dose response". Filter by RCT, meta-analysis, or year on the results page.

Open study
Systematic reviewGoogle Scholar · 1970

Google Scholar: Slippery Elm — clinical evidence

Live Scholar search

Cross-database citation index for Slippery Elm as it relates to "clinical evidence".

Key findings

Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

Open study
Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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