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evidence · mechanism · dose
Supplements/Herb

Artichoke Leaf

aka Cynara scolymus

Cholagogue herb improving dyspepsia and modestly reducing cholesterol.

Gut HealthCardiovascular HealthLiver Health

Overview

Cholagogue herb improving dyspepsia and modestly reducing cholesterol.

Natural sources
  • Cynara scolymus leaf
Common forms
  • Standardized extract

Mechanism of action

Cynarin stimulates bile flow; modulates cholesterol synthesis.

Pathways
  • · Choleresis

Effects on the body

Decreases
Dyspepsia symptoms
Decreases
Total cholesterol (mild)

Organ system effects

Liver

Increases bile flow.

Digestive / Gut

Improves functional dyspepsia.

Evidence-based benefits

Improves functional dyspepsia symptoms

Moderate evidence

Potential side effects

Common
  • · Increased bowel movements
Rare
    Serious

      Drug interactions

      No notable interactions reported.

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid if you are
      • ·Pregnant or breastfeeding (insufficient safety data)
      • ·Children under 18 (unless directed by a clinician)
      Avoid with these conditions
      • ·Bleeding disorders
      Avoid / monitor with these medications
      • ·Warfarin, DOACs, antiplatelets, NSAIDs (additive bleeding risk)
      Before surgery
      • ·Discuss stopping ≥2 weeks before scheduled surgery.

      Supplement interactions

      Pairs well with

      None listed.

      Avoid combining with
      • Bile duct obstruction
        Choleretic.

      Dosing & bioavailability

      Typical dose
      320–640 mg standardized

      Where to buy

      Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Herb
      Artichoke Leaf
      Amazon
      Wide selection · fast shipping
      Herb
      Artichoke Leaf
      iHerb
      Global delivery · curated brands
      Herb
      Artichoke Leaf
      Thorne
      Practitioner-grade · NSF tested

      Scientific evidence (8)

      RCTAliment Pharmacol Ther · 2003

      Artichoke leaf extract for functional dyspepsia

      Holtmann G, et al.

      6-week RCT of artichoke leaf extract.

      Key findings

      Significant symptom relief vs placebo.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Artichoke Leaf — Improves functional dyspepsia symptoms

      Live PubMed search

      Live results for "Artichoke Leaf Improves functional dyspepsia symptoms" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Artichoke Leaf and "Improves functional dyspepsia symptoms". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Artichoke Leaf — randomized controlled trial

      Live PubMed search

      Live results for "Artichoke Leaf randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Artichoke Leaf and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Artichoke Leaf — meta-analysis

      Live PubMed search

      Live results for "Artichoke Leaf meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Artichoke Leaf and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Artichoke Leaf — pharmacokinetics

      Live PubMed search

      Live results for "Artichoke Leaf pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Artichoke Leaf and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Artichoke Leaf — safety adverse events

      Live PubMed search

      Live results for "Artichoke Leaf safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Artichoke Leaf and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Artichoke Leaf — dose response

      Live PubMed search

      Live results for "Artichoke Leaf dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Artichoke Leaf and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Artichoke Leaf — clinical evidence

      Live Scholar search

      Cross-database citation index for Artichoke Leaf as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.