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Liver Health

Phase I/II detox and hepatocyte support.

Ranked by evidence strength across reported benefits.

Amino Acid#1· strong

N-Acetyl Cysteine (NAC)

Glutathione precursor with mucolytic, hepatoprotective, and psychiatric uses.

Herb#2· strong

Milk Thistle

Hepatoprotective herb with antioxidant and anti-fibrotic effects.

Herb#3· strong

Milk Thistle (Silymarin)

Hepatoprotective flavonolignan — best-known liver herb, often used around alcohol exposure.

Herb#4· strong

Milk Thistle (Liver)

Silymarin — most-studied liver herb, used for ALD, NAFLD, and toxin protection.

Compound#5· strong

Choline Bitartrate

Affordable choline source — supports phospholipid synthesis and methylation.

Mineral#6· strong

Molybdenum (Extra)

Cofactor for sulfite oxidase and aldehyde dehydrogenase.

Herb#7· moderate

Curcumin

Yellow polyphenol from turmeric — anti-inflammatory and joint-supportive when properly bioavailable.

Compound#8· moderate

Choline

Essential nutrient for cell membranes, methylation, and acetylcholine synthesis.

Compound#9· moderate

SAMe (S-Adenosyl Methionine)

Universal methyl donor with antidepressant and liver-supportive evidence.

Compound#10· moderate

Glutathione

Master intracellular antioxidant; oral bioavailability depends on form.

Compound#11· moderate

TUDCA

Bile acid with hepatoprotective effects and ER stress reduction.

Compound#12· moderate

Dihydromyricetin (DHM)

Flavonoid from Hovenia dulcis — accelerates alcohol clearance and blunts hangover symptoms.

Amino Acid#13· moderate

NAC (Pre/Post Drinking Use)

Glutathione precursor — bolsters acetaldehyde detoxification before and after alcohol.

Compound#14· moderate

TUDCA (Tauroursodeoxycholic Acid)

Conjugated bile acid — hepatoprotective and ER-stress-reducing.

Compound#15· moderate

Sulforaphane (Broccoli Sprout)

Most potent natural Nrf2 activator — upregulates phase II detox enzymes.

Herb#16· moderate

Artichoke Leaf Extract

Choleretic herb — supports bile flow, gallbladder, and mild lipid lowering.

Mineral#17· moderate

Molybdenum

Trace mineral cofactor for xanthine oxidase and sulfite oxidase.

Herb#18· moderate

Schisandra

Adaptogenic berry traditionally used for stamina, liver protection, and stress resilience.

Herb#19· moderate

Artichoke Leaf

Cholagogue herb improving dyspepsia and modestly reducing cholesterol.

Herb#20· moderate

Silymarin (Liver Dose)

Standardized silybin-rich extract for liver disease.

Compound#21· moderate

Betaine (Liver)

TMG methyl donor used for fatty liver and homocysteinemia.

Herb#22· moderate

Schisandra (Adaptogen)

Berry adaptogen for stress, focus, and liver protection.

Herb#23· moderate

Kudzu (Pueraria lobata)

Isoflavone-rich root that reduces alcohol intake.

Compound#24· moderate

Phosphatidylcholine (PC)

Major brain and hepatic phospholipid often given for liver support.

Compound#25· moderate

Lactulose

Non-absorbable disaccharide for constipation and HE.

Amino Acid#26· moderate

L-Ornithine

Urea cycle amino acid for ammonia clearance.

Herb#27· moderate

Silymarin (Milk Thistle)

Silybum marianum flavonolignans for liver.

Compound#28· moderate

Silybin

Most active milk thistle flavonolignan.

Herb#29· moderate

Siliphos (Silybin Phytosome)

Silybin-phosphatidylcholine complex.

Herb#30· moderate

Picrorhiza Kurroa

Indian herb for liver protection.

Compound#31· moderate

Soy Lecithin

Phosphatidylcholine source.

Compound#32· moderate

Phosphatidylcholine

Membrane phospholipid for liver.

Compound#33· moderate

Trimethylglycine (Betaine)

Same as TMG; osmolyte and methyl donor.

Vitamin#34· limited

Tocotrienols (Vitamin E)

Unsaturated vitamin E family — superior antioxidant capacity vs alpha-tocopherol.

Compound#35· limited

Calcium D-Glucarate

Beta-glucuronidase inhibitor promoting elimination of conjugated hormones/toxins.

Amino Acid#36· limited

ALCAR (Pre-Drinking)

Mitochondrial cofactor that may reduce acetaldehyde-induced oxidative stress.

Compound#37· limited

Calcium-D-Glucarate

Inhibits β-glucuronidase to support estrogen and toxin elimination via the liver.

Compound#38· limited

Liposomal Glutathione

Phospholipid-encapsulated GSH — protects from gut breakdown for systemic delivery.

Compound#39· limited

S-Acetyl Glutathione

Acetylated GSH — stable through the gut and converted intracellularly to glutathione.

Compound#40· limited

Dihydromyricetin (Extra)

Hovenia dulcis flavanonol that accelerates ethanol clearance.