Overview
Hovenia dulcis flavanonol that accelerates ethanol clearance.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Forms & variants of Dihydromyricetin (DHM)
Different chemical forms of Dihydromyricetin (DHM) behave differently. Browse each form's mechanism, bioavailability, and best-use context.
Mechanism of action
Upregulates alcohol and aldehyde dehydrogenases; positive allosteric modulator at GABA-A α1.
- · Upregulates alcohol
- · aldehyde dehydrogenases
- · positive allosteric modulator at GABA-A α1
Effects on the body
Organ system effects
Dihydromyricetin (Extra) supports hepatocyte antioxidant defenses (glutathione, Nrf2) and phase-I/II detoxification.
Evidence-based benefits
Reduces hangover severity in small trials
Limited evidencePotential side effects
- · GI upset
Drug interactions
Supplement interactions
- Milk thistle (silymarin)Complementary hepatoprotective antioxidant pathways.
- NACRestores hepatic glutathione.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Dihydromyricetin (Extra) — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Dihydromyricetin (Extra) third party tested NSF
CapsulesPre-measured Dihydromyricetin (Extra) capsules — easiest for travel and consistent daily dosing without scoops or scales.Dihydromyricetin (Extra) capsules
PowderBulk unflavored Dihydromyricetin (Extra) powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Dihydromyricetin (Extra) powder unflavored
Best sellersMost-purchased Dihydromyricetin (Extra) products on Amazon — a quick way to see what's reviewed widely before you commit.Dihydromyricetin (Extra) best sellerScientific evidence8Show studiesHide studies
DHM in alcohol intoxication (rat)
Shen Y, et al.
Rats given ethanol with or without DHM.
DHM reduced sedation, withdrawal, and ethanol preference.
PubMed: Dihydromyricetin (Extra) — Reduces hangover severity in small trials
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