SYS ONLINE
SUPPLEMENT_SCHOLAR
evidence · mechanism · dose
Supplements/Compound

Dihydromyricetin (Extra)

Hovenia dulcis flavanonol that accelerates ethanol clearance.

Liver Health

Overview

Hovenia dulcis flavanonol that accelerates ethanol clearance.

Natural sources
    Common forms

      Forms & variants of Dihydromyricetin (DHM)

      Different chemical forms of Dihydromyricetin (DHM) behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Dihydromyricetin (DHM)

      Flavonoid from Hovenia dulcis — accelerates alcohol clearance and blunts hangover symptoms.

      Mechanism of action

      Upregulates alcohol and aldehyde dehydrogenases; positive allosteric modulator at GABA-A α1.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces hangover severity in small trials

        Limited evidence

        Potential side effects

        Common
        • · GI upset
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            300–600 mg before and after drinking
            With food?
            With food

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
            Dihydromyric…
            Amazon
            Wide selection · fast shipping
            Compound
            Dihydromyric…
            iHerb
            Global delivery · curated brands
            Compound
            Dihydromyric…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            AnimalJ Neurosci · 2012

            DHM in alcohol intoxication (rat)

            Shen Y, et al.

            Rats given ethanol with or without DHM.

            Key findings

            DHM reduced sedation, withdrawal, and ethanol preference.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Dihydromyricetin (Extra) — Reduces hangover severity in small trials

            Live PubMed search

            Live results for "Dihydromyricetin (Extra) Reduces hangover severity in small trials" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Dihydromyricetin (Extra) and "Reduces hangover severity in small trials". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Dihydromyricetin (Extra) — randomized controlled trial

            Live PubMed search

            Live results for "Dihydromyricetin (Extra) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Dihydromyricetin (Extra) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Dihydromyricetin (Extra) — meta-analysis

            Live PubMed search

            Live results for "Dihydromyricetin (Extra) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Dihydromyricetin (Extra) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Dihydromyricetin (Extra) — pharmacokinetics

            Live PubMed search

            Live results for "Dihydromyricetin (Extra) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Dihydromyricetin (Extra) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Dihydromyricetin (Extra) — safety adverse events

            Live PubMed search

            Live results for "Dihydromyricetin (Extra) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Dihydromyricetin (Extra) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Dihydromyricetin (Extra) — dose response

            Live PubMed search

            Live results for "Dihydromyricetin (Extra) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Dihydromyricetin (Extra) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Dihydromyricetin (Extra) — clinical evidence

            Live Scholar search

            Cross-database citation index for Dihydromyricetin (Extra) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.