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evidence · mechanism · dose
Supplements/Compound

Dihydromyricetin (DHM)

aka Hovenia dulcis flavonoid · Ampelopsin

Flavonoid from Hovenia dulcis — accelerates alcohol clearance and blunts hangover symptoms.

Pre-Drinking SupportPost-Drinking RecoveryLiver Health

Overview

A flavonoid from oriental raisin tree, traditionally used in Asia to mitigate intoxication and hangovers.

Natural sources
    Common forms

      Forms & variants of Dihydromyricetin (DHM)

      Different chemical forms of Dihydromyricetin (DHM) behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Hangover protocol
      Dihydromyricetin (Extra)

      Hovenia dulcis flavanonol that accelerates ethanol clearance.

      Mechanism of action

      Upregulates ADH and ALDH activity; blocks alcohol's potentiation of GABA-A receptors, reducing intoxication and rebound anxiety.

      Pathways
      • · ADH/ALDH upregulation
      • · GABA-A α1 modulation
      • · Liver glutathione support

      Effects on the body

      Increases
      Alcohol clearance rate
      Decreases
      Acetaldehyde accumulation
      Decreases
      Hangover severity

      Organ system effects

      Liver

      Reduces ALT/AST elevation after alcohol challenge in animals.

      Brain & CNS

      Blocks alcohol's GABA-A binding (Shen 2012).

      Evidence-based benefits

      Reduces hangover symptoms in human trials

      Limited evidence

      Animal evidence for ALD prevention

      Moderate evidence

      Potential side effects

      Common
      • · Mild GI
      Rare
        Serious

          Drug interactions

          No notable interactions reported.

          Safety & non-supplemental interactions

          Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

          Other notes
          • ·Discuss with a clinician if you have active liver disease or take hepatotoxic medications.

          Supplement interactions

          Pairs well with
          • NAC
            Glutathione substrate for acetaldehyde clearance.
          • Electrolytes
            Counter alcohol-induced diuresis.
          Avoid combining with

          No specific avoidances listed.

          Dosing & bioavailability

          Typical dose
          300–600 mg before drinking; repeat before bed
          Study range
          300–1200 mg
          With food?
          Before alcohol

          Where to buy

          Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

          Compound
          Dihydromyric…
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          Wide selection · fast shipping
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          iHerb
          Global delivery · curated brands
          Compound
          Dihydromyric…
          Thorne
          Practitioner-grade · NSF tested

          Scientific evidence (9)

          AnimalJ Neuroscience · 2012

          Dihydromyricetin as a novel anti-alcohol intoxication medication

          Shen Y et al.

          DHM blocked alcohol intoxication and reduced withdrawal anxiety in rats.

          Key findings

          Counteracted alcohol's potentiation of GABA-A receptors.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Dihydromyricetin (DHM) — Reduces hangover symptoms in human trials

          Live PubMed search

          Live results for "Dihydromyricetin (DHM) Reduces hangover symptoms in human trials" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Dihydromyricetin (DHM) and "Reduces hangover symptoms in human trials". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Dihydromyricetin (DHM) — Animal evidence for ALD prevention

          Live PubMed search

          Live results for "Dihydromyricetin (DHM) Animal evidence for ALD prevention" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Dihydromyricetin (DHM) and "Animal evidence for ALD prevention". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Dihydromyricetin (DHM) — randomized controlled trial

          Live PubMed search

          Live results for "Dihydromyricetin (DHM) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Dihydromyricetin (DHM) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Dihydromyricetin (DHM) — meta-analysis

          Live PubMed search

          Live results for "Dihydromyricetin (DHM) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Dihydromyricetin (DHM) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Dihydromyricetin (DHM) — pharmacokinetics

          Live PubMed search

          Live results for "Dihydromyricetin (DHM) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Dihydromyricetin (DHM) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Dihydromyricetin (DHM) — safety adverse events

          Live PubMed search

          Live results for "Dihydromyricetin (DHM) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Dihydromyricetin (DHM) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Dihydromyricetin (DHM) — dose response

          Live PubMed search

          Live results for "Dihydromyricetin (DHM) dose response" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Dihydromyricetin (DHM) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewGoogle Scholar · 1970

          Google Scholar: Dihydromyricetin (DHM) — clinical evidence

          Live Scholar search

          Cross-database citation index for Dihydromyricetin (DHM) as it relates to "clinical evidence".

          Key findings

          Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

          Open study
          Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.