Overview
A flavonoid from oriental raisin tree, traditionally used in Asia to mitigate intoxication and hangovers.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Forms & variants of Dihydromyricetin (DHM)
Different chemical forms of Dihydromyricetin (DHM) behave differently. Browse each form's mechanism, bioavailability, and best-use context.
Mechanism of action
Upregulates ADH and ALDH activity; blocks alcohol's potentiation of GABA-A receptors, reducing intoxication and rebound anxiety.
- · ADH/ALDH upregulation
- · GABA-A α1 modulation
- · Liver glutathione support
Effects on the body
Organ system effects
Reduces ALT/AST elevation after alcohol challenge in animals.
Blocks alcohol's GABA-A binding (Shen 2012).
Evidence-based benefits
Reduces hangover symptoms in human trials
Limited evidenceAnimal evidence for ALD prevention
Moderate evidencePotential side effects
- · Mild GI
Drug interactions
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Discuss with a clinician if you have active liver disease or take hepatotoxic medications.
Supplement interactions
- NACGlutathione substrate for acetaldehyde clearance.
- ElectrolytesCounter alcohol-induced diuresis.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.
Third-party testedIndependently verified Dihydromyricetin (DHM) — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Dihydromyricetin (DHM) third party tested NSF
CapsulesPre-measured Dihydromyricetin (DHM) capsules — easiest for travel and consistent daily dosing without scoops or scales.Dihydromyricetin (DHM) capsules
PowderBulk unflavored Dihydromyricetin (DHM) powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Dihydromyricetin (DHM) powder unflavored
Best sellersMost-purchased Dihydromyricetin (DHM) products on Amazon — a quick way to see what's reviewed widely before you commit.Dihydromyricetin (DHM) best sellerScientific evidence9Show studiesHide studies
Dihydromyricetin as a novel anti-alcohol intoxication medication
Shen Y et al.
DHM blocked alcohol intoxication and reduced withdrawal anxiety in rats.
Counteracted alcohol's potentiation of GABA-A receptors.
PubMed: Dihydromyricetin (DHM) — Reduces hangover symptoms in human trials
Live PubMed search
Live results for "Dihydromyricetin (DHM) Reduces hangover symptoms in human trials" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Dihydromyricetin (DHM) and "Reduces hangover symptoms in human trials". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Dihydromyricetin (DHM) — Animal evidence for ALD prevention
Live PubMed search
Live results for "Dihydromyricetin (DHM) Animal evidence for ALD prevention" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Dihydromyricetin (DHM) and "Animal evidence for ALD prevention". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Dihydromyricetin (DHM) — randomized controlled trial
Live PubMed search
Live results for "Dihydromyricetin (DHM) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Dihydromyricetin (DHM) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Dihydromyricetin (DHM) — meta-analysis
Live PubMed search
Live results for "Dihydromyricetin (DHM) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Dihydromyricetin (DHM) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Dihydromyricetin (DHM) — pharmacokinetics
Live PubMed search
Live results for "Dihydromyricetin (DHM) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Dihydromyricetin (DHM) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Dihydromyricetin (DHM) — safety adverse events
Live PubMed search
Live results for "Dihydromyricetin (DHM) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Dihydromyricetin (DHM) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Dihydromyricetin (DHM) — dose response
Live PubMed search
Live results for "Dihydromyricetin (DHM) dose response" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Dihydromyricetin (DHM) and "dose response". Filter by RCT, meta-analysis, or year on the results page.
Google Scholar: Dihydromyricetin (DHM) — clinical evidence
Live Scholar search
Cross-database citation index for Dihydromyricetin (DHM) as it relates to "clinical evidence".
Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.