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evidence · mechanism · dose
Supplements/Compound

Betaine (Liver)

TMG methyl donor used for fatty liver and homocysteinemia.

Liver HealthCardiovascular Health

Overview

TMG methyl donor used for fatty liver and homocysteinemia.

Natural sources
    Common forms

      Forms & variants of Betaine Anhydrous (TMG)

      Different chemical forms of Betaine Anhydrous (TMG) behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Betaine Anhydrous (TMG)

      Methyl donor — improves power output and lowers homocysteine.

      Strength dose
      Betaine (Strength)

      Methyl donor used for power output and body composition.

      Mechanism of action

      Provides methyl groups for homocysteine remethylation and phosphatidylcholine synthesis.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves steatosis in NAFLD

        Moderate evidence

        Potential side effects

        Common
        • · Fishy odor
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            10–20 g/day
            With food?
            With meals

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
            Betaine (Liv…
            Amazon
            Wide selection · fast shipping
            Compound
            Betaine (Liv…
            iHerb
            Global delivery · curated brands
            Compound
            Betaine (Liv…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTHepatology · 2009

            Betaine in NASH

            Abdelmalek MF, et al.

            12-month DB-RCT in 55 NASH patients.

            Key findings

            No improvement in fibrosis but improved steatosis grade.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Betaine (Liver) — Improves steatosis in NAFLD

            Live PubMed search

            Live results for "Betaine (Liver) Improves steatosis in NAFLD" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Betaine (Liver) and "Improves steatosis in NAFLD". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Betaine (Liver) — randomized controlled trial

            Live PubMed search

            Live results for "Betaine (Liver) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Betaine (Liver) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Betaine (Liver) — meta-analysis

            Live PubMed search

            Live results for "Betaine (Liver) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Betaine (Liver) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Betaine (Liver) — pharmacokinetics

            Live PubMed search

            Live results for "Betaine (Liver) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Betaine (Liver) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Betaine (Liver) — safety adverse events

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            Live results for "Betaine (Liver) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Betaine (Liver) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Betaine (Liver) — dose response

            Live PubMed search

            Live results for "Betaine (Liver) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Betaine (Liver) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Betaine (Liver) — clinical evidence

            Live Scholar search

            Cross-database citation index for Betaine (Liver) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.