Overview
TMG methyl donor used for fatty liver and homocysteinemia.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Forms & variants of Betaine Anhydrous (TMG)
Different chemical forms of Betaine Anhydrous (TMG) behave differently. Browse each form's mechanism, bioavailability, and best-use context.
Mechanism of action
Provides methyl groups for homocysteine remethylation and phosphatidylcholine synthesis.
- · Provides methyl groups for homocysteine remethylation
- · phosphatidylcholine synthesis
Effects on the body
Organ system effects
Betaine (Liver) supports hepatocyte antioxidant defenses (glutathione, Nrf2) and phase-I/II detoxification.
Betaine (Liver) supports endothelial function, lipid profile, or blood-pressure regulation in cardiovascular trials.
Evidence-based benefits
Improves steatosis in NAFLD
Moderate evidencePotential side effects
- · Fishy odor
Drug interactions
Supplement interactions
- Milk thistle (silymarin)Complementary hepatoprotective antioxidant pathways.
- NACRestores hepatic glutathione.
- Omega-3Anti-inflammatory cardiovascular synergy.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Betaine (Liver) — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Betaine (Liver) third party tested NSF
CapsulesPre-measured Betaine (Liver) capsules — easiest for travel and consistent daily dosing without scoops or scales.Betaine (Liver) capsules
PowderBulk unflavored Betaine (Liver) powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Betaine (Liver) powder unflavored
Best sellersMost-purchased Betaine (Liver) products on Amazon — a quick way to see what's reviewed widely before you commit.Betaine (Liver) best sellerScientific evidence8Show studiesHide studies
Betaine in NASH
Abdelmalek MF, et al.
12-month DB-RCT in 55 NASH patients.
No improvement in fibrosis but improved steatosis grade.
PubMed: Betaine (Liver) — Improves steatosis in NAFLD
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PubMed: Betaine (Liver) — randomized controlled trial
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PubMed: Betaine (Liver) — dose response
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Google Scholar: Betaine (Liver) — clinical evidence
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Cross-database citation index for Betaine (Liver) as it relates to "clinical evidence".
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