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evidence · mechanism · dose
Supplements/Compound

Betaine Anhydrous (TMG)

aka Trimethylglycine

Methyl donor — improves power output and lowers homocysteine.

Athletic PerformanceCardiovascular HealthMuscle Growth

Overview

Methyl donor — improves power output and lowers homocysteine.

Natural sources
    Common forms

      Forms & variants of Betaine Anhydrous (TMG)

      Different chemical forms of Betaine Anhydrous (TMG) behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Strength dose
      Betaine (Strength)

      Methyl donor used for power output and body composition.

      Liver dose
      Betaine (Liver)

      TMG methyl donor used for fatty liver and homocysteinemia.

      Mechanism of action

      Methyl donor for methionine cycle (BHMT pathway); osmolyte stabilizing muscle cells.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves power output

        Moderate evidence

        Lowers homocysteine

        Strong evidence

        Potential side effects

        Common
          Rare
            Serious

              Drug interactions

              No notable interactions reported.

              Supplement interactions

              Pairs well with

              None listed.

              Avoid combining with

              No specific avoidances listed.

              Dosing & bioavailability

              Typical dose
              2.5 g/d
              With food?
              Optional

              Where to buy

              Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

              Compound
              Betaine Anhy…
              Amazon
              Wide selection · fast shipping
              Compound
              Betaine Anhy…
              iHerb
              Global delivery · curated brands
              Compound
              Betaine Anhy…
              Thorne
              Practitioner-grade · NSF tested

              Scientific evidence (9)

              RCTJ Int Soc Sports Nutr · 2013

              Betaine on strength and body composition

              Cholewa JM, et al.

              6-week RCT of betaine in resistance-trained males.

              Key findings

              Improved body composition and strength.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Betaine Anhydrous (TMG) — Improves power output

              Live PubMed search

              Live results for "Betaine Anhydrous (TMG) Improves power output" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Betaine Anhydrous (TMG) and "Improves power output". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Betaine Anhydrous (TMG) — Lowers homocysteine

              Live PubMed search

              Live results for "Betaine Anhydrous (TMG) Lowers homocysteine" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Betaine Anhydrous (TMG) and "Lowers homocysteine". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Betaine Anhydrous (TMG) — randomized controlled trial

              Live PubMed search

              Live results for "Betaine Anhydrous (TMG) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Betaine Anhydrous (TMG) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Betaine Anhydrous (TMG) — meta-analysis

              Live PubMed search

              Live results for "Betaine Anhydrous (TMG) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Betaine Anhydrous (TMG) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Betaine Anhydrous (TMG) — pharmacokinetics

              Live PubMed search

              Live results for "Betaine Anhydrous (TMG) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Betaine Anhydrous (TMG) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Betaine Anhydrous (TMG) — safety adverse events

              Live PubMed search

              Live results for "Betaine Anhydrous (TMG) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Betaine Anhydrous (TMG) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Betaine Anhydrous (TMG) — dose response

              Live PubMed search

              Live results for "Betaine Anhydrous (TMG) dose response" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Betaine Anhydrous (TMG) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewGoogle Scholar · 1970

              Google Scholar: Betaine Anhydrous (TMG) — clinical evidence

              Live Scholar search

              Cross-database citation index for Betaine Anhydrous (TMG) as it relates to "clinical evidence".

              Key findings

              Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

              Open study
              Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.