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evidence · mechanism · dose
Supplements/Compound

Betaine (Strength)

Methyl donor used for power output and body composition.

Athletic PerformanceMuscle Growth

Overview

Methyl donor used for power output and body composition.

Natural sources
    Common forms

      Forms & variants of Betaine Anhydrous (TMG)

      Different chemical forms of Betaine Anhydrous (TMG) behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Betaine Anhydrous (TMG)

      Methyl donor — improves power output and lowers homocysteine.

      Liver dose
      Betaine (Liver)

      TMG methyl donor used for fatty liver and homocysteinemia.

      Mechanism of action

      Osmolyte and methyl donor for creatine and homocysteine metabolism.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves power output

        Moderate evidence

        Potential side effects

        Common
        • · Fishy odor
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            2.5 g/day
            With food?
            Either

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
            Betaine (Str…
            Amazon
            Wide selection · fast shipping
            Compound
            Betaine (Str…
            iHerb
            Global delivery · curated brands
            Compound
            Betaine (Str…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTJ Int Soc Sports Nutr · 2010

            Betaine on strength

            Lee EC, et al.

            14-day DB-RCT in trained men.

            Key findings

            Improved bench-press power and vertical jump.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Betaine (Strength) — Improves power output

            Live PubMed search

            Live results for "Betaine (Strength) Improves power output" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Betaine (Strength) and "Improves power output". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Betaine (Strength) — randomized controlled trial

            Live PubMed search

            Live results for "Betaine (Strength) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Betaine (Strength) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Betaine (Strength) — meta-analysis

            Live PubMed search

            Live results for "Betaine (Strength) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Betaine (Strength) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Betaine (Strength) — pharmacokinetics

            Live PubMed search

            Live results for "Betaine (Strength) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Betaine (Strength) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Betaine (Strength) — safety adverse events

            Live PubMed search

            Live results for "Betaine (Strength) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Betaine (Strength) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Betaine (Strength) — dose response

            Live PubMed search

            Live results for "Betaine (Strength) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Betaine (Strength) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Betaine (Strength) — clinical evidence

            Live Scholar search

            Cross-database citation index for Betaine (Strength) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.