Overview
Most active milk thistle flavonolignan.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Stabilizes hepatocyte membranes; antioxidant.
- · Stabilizes hepatocyte membranes
- · antioxidant
Effects on the body
Organ system effects
Silybin supports hepatocyte antioxidant defenses (glutathione, Nrf2) and phase-I/II detoxification.
Evidence-based benefits
Hepatoprotective
Moderate evidencePotential side effects
- · GI upset
Drug interactions
Supplement interactions
- Milk thistle (silymarin)Complementary hepatoprotective antioxidant pathways.
- NACRestores hepatic glutathione.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.
Third-party testedIndependently verified Silybin — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Silybin third party tested NSF
CapsulesPre-measured Silybin capsules — easiest for travel and consistent daily dosing without scoops or scales.Silybin capsules
PowderBulk unflavored Silybin powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Silybin powder unflavored
Best sellersMost-purchased Silybin products on Amazon — a quick way to see what's reviewed widely before you commit.Silybin best sellerScientific evidence8Show studiesHide studies
Silybin in Amanita poisoning
Mengs U, et al.
Clinical case series
Reduced mortality in mushroom poisoning.
PubMed: Silybin — Hepatoprotective
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PubMed: Silybin — randomized controlled trial
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PubMed: Silybin — meta-analysis
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PubMed: Silybin — pharmacokinetics
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PubMed: Silybin — safety adverse events
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PubMed: Silybin — dose response
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Google Scholar: Silybin — clinical evidence
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