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evidence · mechanism · dose
Supplements/Herb

Artichoke Leaf Extract

Choleretic herb — supports bile flow, gallbladder, and mild lipid lowering.

Gallbladder HealthLiver HealthCholesterolDigestion

Overview

Choleretic herb — supports bile flow, gallbladder, and mild lipid lowering.

Natural sources
    Common forms

      Mechanism of action

      Cynarin increases bile flow and inhibits cholesterol synthesis.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves functional dyspepsia

        Moderate evidence

        Modest LDL reduction

        Limited evidence

        Potential side effects

        Common
          Rare
          • · Allergic reaction (Asteraceae)
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            320–640 mg standardized
            With food?
            With meals

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Herb
            Artichoke Le…
            Amazon
            Wide selection · fast shipping
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            iHerb
            Global delivery · curated brands
            Herb
            Artichoke Le…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (9)

            RCTAliment Pharmacol Ther · 2003

            Artichoke leaf extract for functional dyspepsia

            Holtmann G, et al.

            6-week RCT of artichoke leaf extract.

            Key findings

            Significant symptom relief vs placebo.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Artichoke Leaf Extract — Improves functional dyspepsia

            Live PubMed search

            Live results for "Artichoke Leaf Extract Improves functional dyspepsia" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Artichoke Leaf Extract and "Improves functional dyspepsia". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Artichoke Leaf Extract — Modest LDL reduction

            Live PubMed search

            Live results for "Artichoke Leaf Extract Modest LDL reduction" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Artichoke Leaf Extract and "Modest LDL reduction". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Artichoke Leaf Extract — randomized controlled trial

            Live PubMed search

            Live results for "Artichoke Leaf Extract randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Artichoke Leaf Extract and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Artichoke Leaf Extract — meta-analysis

            Live PubMed search

            Live results for "Artichoke Leaf Extract meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Artichoke Leaf Extract and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Artichoke Leaf Extract — pharmacokinetics

            Live PubMed search

            Live results for "Artichoke Leaf Extract pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Artichoke Leaf Extract and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Artichoke Leaf Extract — safety adverse events

            Live PubMed search

            Live results for "Artichoke Leaf Extract safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Artichoke Leaf Extract and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Artichoke Leaf Extract — dose response

            Live PubMed search

            Live results for "Artichoke Leaf Extract dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Artichoke Leaf Extract and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Artichoke Leaf Extract — clinical evidence

            Live Scholar search

            Cross-database citation index for Artichoke Leaf Extract as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.