Cholesterol
LDL/HDL/ApoB modulation.
Ranked by evidence strength across reported benefits.
Magnesium
Essential cofactor in 300+ enzymatic reactions, from ATP production to muscle relaxation.
Omega-3 (EPA/DHA)
Marine long-chain omega-3s — the most-studied anti-inflammatory and cardiovascular nutrient.
Vitamin B3 (Niacin)
NAD+ precursor; nicotinic acid form lowers LDL and raises HDL.
Psyllium Husk
Soluble fiber with strong evidence for cholesterol reduction and bowel regularity.
Psyllium Husk
Viscous soluble fiber — lowers cholesterol, glucose, and supports regularity.
Potassium
Major intracellular cation essential for BP control, muscle function, and acid-base balance.
Garlic
Culinary bulb with cardiovascular benefits primarily via allicin and aged-garlic compounds.
Beetroot Juice
Dietary nitrate source improving NO production, BP, and endurance performance.
Beta-Glucan
Polysaccharide that primes innate immune cells (yeast) or lowers cholesterol (oat).
Betaine Anhydrous (TMG)
Methyl donor — improves power output and lowers homocysteine.
Aged Garlic Extract (Kyolic)
Odorless aged garlic with S-allyl-cysteine for vascular health.
Red Yeast Rice
Fermented rice product containing natural monacolin K (chemically identical to lovastatin).
Phytosterols (Plant Sterols)
Plant sterols/stanols competitively inhibit cholesterol absorption.
Algal Omega-3 (Vegan EPA/DHA)
Plant-based EPA and DHA from microalgae for vegan diets.
Red Yeast Rice
Naturally contains monacolin K (chemically identical to lovastatin) — same risks as statins.
Omega-3 (rTG form)
Re-esterified triglyceride EPA/DHA — ~70% better absorption than ethyl ester form.
Omega-3 (Ethyl Ester)
Concentrated EE form found in most prescription and budget fish oils — cheaper, less bioavailable.
Algal Omega-3 (DHA/EPA)
Plant-source DHA (and some EPA) from cultivated marine algae — vegan alternative to fish oil.
Ubiquinone (CoQ10)
Standard oxidized CoQ10 — cheaper and effective in younger adults who can readily reduce it.
Niacin (Flush)
Flushing form of B3 — historically used for dyslipidemia at gram doses.
Magnesium Sulfate (IV)
Reference IV form used in eclampsia and acute asthma.
EPA-Only Omega-3
Pure EPA reduces residual cardiovascular risk on statins.
Vitamin K1 (Phylloquinone)
Leafy-green K1 essential for hepatic coagulation factors.
Vitamin K2 (MK-7)
Activates the proteins that direct calcium into bone — not arteries.
Berberine
Plant alkaloid that activates AMPK — metformin-like effects on glucose and lipids.
Coenzyme Q10
Mitochondrial electron carrier and lipid-soluble antioxidant.
Vitamin E
Primary lipid-phase antioxidant protecting membrane PUFAs.
L-Arginine
Conditionally essential amino acid and direct nitric oxide precursor.
Pomegranate
Polyphenol-rich fruit converted by gut microbes to urolithin A (mitochondrial benefit).
Green Tea (EGCG)
Polyphenol-rich tea; EGCG modestly boosts metabolism and supports cardiovascular health.
Soy Isoflavones
Phytoestrogens with mild SERM effects on bone, hot flashes, and lipids.
Ubiquinol (CoQ10)
Reduced active form of CoQ10 — preferred in adults over 40 and those with statin-induced depletion.
Vitamin K2 (MK-7)
Long-half-life K2 — directs calcium to bone and away from arteries.
Taurine
Conditionally essential amino acid involved in bile salt conjugation, osmoregulation, and cardiac function.
L-Citrulline
Arginine precursor with superior bioavailability for NO and pump-driven performance.
Bilberry
Anthocyanin-rich berry traditionally used for night vision and vascular support.
Resveratrol
Polyphenol from grapes — sirtuin activator with mixed human evidence.
Taurine
Conditionally essential amino acid with cardiovascular, metabolic, and longevity effects.
Artichoke Leaf Extract
Choleretic herb — supports bile flow, gallbladder, and mild lipid lowering.
Krill Oil
Phospholipid-bound EPA/DHA from Antarctic krill — includes astaxanthin antioxidant.
Taurine (High-Dose)
Conditionally essential amino acid with longevity and metabolic effects.
Vitamin D3 + K2 Synergy Note
Combined fat-soluble vitamins addressing calcium destination (bone vs artery).
Shiitake (Lentinan)
Culinary mushroom whose beta-glucan lentinan is an approved injectable immune adjunct.
Hawthorn
Cardiotonic herb traditionally used for mild heart failure and mild hypertension.
Olive Leaf Extract
Mediterranean herb with antihypertensive and immune effects.
Artichoke Leaf
Cholagogue herb improving dyspepsia and modestly reducing cholesterol.
Bergamot Extract
Standardized citrus polyphenol fraction shown to lower LDL and triglycerides.
Krill Oil
Phospholipid-bound omega-3 with astaxanthin; better bioavailability than fish oil per gram.
Resveratrol
Polyphenol activating sirtuins; bioavailability and clinical effects modest.
Aged Garlic Extract (Kyolic)
Standardized aged garlic — modest BP and cholesterol benefits.
Bergamot Polyphenols
Standardized citrus extract — significant LDL and triglyceride reduction.
Hawthorn (Crataegus)
Cardiotonic herb traditionally used in early-stage heart failure.
Lycopene
Tomato carotenoid linked with prostate and cardiovascular protection.
Nattokinase
Fermented soy serine protease with fibrinolytic activity.
Lumbrokinase
Earthworm-derived fibrinolytic enzyme complex.
Pterostilbene (Extra)
Methylated resveratrol analog with superior bioavailability.
Betaine (Liver)
TMG methyl donor used for fatty liver and homocysteinemia.
Trans-Resveratrol (Pure)
Purified active isomer of resveratrol.
Mixed Tocopherols
Full-spectrum natural vitamin E avoiding α-only supplementation pitfalls.
Hawthorn Berry
Crataegus for mild heart failure and BP support.
Arjuna
Terminalia arjuna bark for cardiovascular support.
Horse Chestnut
Aesculus seed extract for chronic venous insufficiency.
Butcher's Broom
Ruscus aculeatus for venous insufficiency.
Centella Triterpene Fraction
Standardized madecassoside/asiaticoside for skin and venous health.
SS-31 (Elamipretide)
Mitochondrial-targeted peptide for cardiolipin protection.
MitoQ
Mitochondria-targeted ubiquinone (CoQ10 analog).
Hydroxytyrosol
Olive polyphenol for cardiovascular health.
Squalene
Olive oil/shark liver lipid antioxidant.
Bergamot Extract
Citrus bergamia for cardiometabolic support.
Inositol Hexanicotinate (No-Flush Niacin)
Niacin form without flushing.
Niacin Extended Release
Slow-release nicotinic acid for cholesterol.
Plant Sterols/Stanols
Phytosterols for cholesterol lowering.
Psyllium Husk
Soluble fiber from Plantago ovata.
Vitamin D3 + K2
Synergistic combo for calcium routing.
Quercetin Phytosome
Lecithin-complexed quercetin.
Rutin
Quercetin-rutinoside for venous health.
Diosmin + Hesperidin
Citrus flavonoid pair for venous insufficiency.
Beta-Sitosterol
Plant sterol for BPH and cholesterol.
Isoquercetin
Highly bioavailable quercetin glycoside.
Oyster Mushroom
Pleurotus ostreatus with ergothioneine.
TMG (Betaine Anhydrous)
Methyl donor for homocysteine reduction.
Trimethylglycine (Betaine)
Same as TMG; osmolyte and methyl donor.
Ginkgo Biloba EGb 761
Standardized Ginkgo for cognition.
Type III Collagen
Skin and vascular collagen.
2S-Hesperidin (Cardiose)
Bioactive isomer of hesperidin.
Enzogenol
New Zealand pine bark extract.
Pycnogenol (Pine Bark)
French maritime pine bark for circulation.
Grape Seed Extract
Vitis vinifera procyanidins.
Trans-Resveratrol
Active form of resveratrol.
Pomegranate Extract
Punica granatum ellagitannins.
Punicalagin
Major pomegranate ellagitannin.
Olive Leaf (Standardized Oleuropein)
High-oleuropein extract.
Black Seed Oil (Nigella sativa)
Thymoquinone for immune and metabolic health.
Apple Pectin
Soluble fiber from apples.
Beetroot Nitrate
Inorganic nitrate for NO production.
(−)-Epicatechin
Cocoa flavanol for follistatin/myostatin.
EVOO Polyphenols
Extra virgin olive oil polyphenols.
EPA-Dominant Fish Oil
Concentrated EPA for inflammation.
Algae Omega-3
Vegan EPA/DHA source.
Flax Seed Oil (ALA)
Alpha-linolenic acid omega-3.
Chia Seed
Salvia hispanica ALA source.
Hemp Seed Oil
3:1 omega-6 to omega-3 ratio.
Salmon Roe Phospholipids
Phospholipid omega-3s from salmon eggs.
Perilla Oil
High ALA from Perilla frutescens.
Guggul (Commiphora mukul)
Ayurvedic resin used historically for cholesterol and thyroid support.
Magnesium Taurate
Magnesium + taurine — gentle on the gut with cardiovascular and glycemic synergies.
Magnesium Orotate
Magnesium + orotic acid — studied specifically in heart failure and athletic populations.
Tocotrienols (Vitamin E)
Unsaturated vitamin E family — superior antioxidant capacity vs alpha-tocopherol.
Policosanol
Long-chain alcohols from sugarcane wax marketed for cholesterol; Cuban studies positive but unreplicated.
Pterostilbene
Bioavailable resveratrol analog with longer half-life.
Policosanol
Sugar cane alcohols — mixed evidence for lipid lowering (Cuban trials positive, others negative).
Cuban Policosanol
Sugar-cane–derived lipid-lowering long-chain alcohols.