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evidence · mechanism · dose
Supplements/Compound

Lumbrokinase

Earthworm-derived fibrinolytic enzyme complex.

Cardiovascular Health

Overview

Earthworm-derived fibrinolytic enzyme complex.

Natural sources
    Common forms

      Mechanism of action

      Directly digests fibrin and activates plasminogen; lowers blood viscosity.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves outcomes in acute ischemic stroke (Chinese trials)

        Moderate evidence

        Potential side effects

        Common
        • · GI upset
        Rare
          Serious
          • · Bleeding risk

          Drug interactions

          Anticoagulants
          Avoid combination.
          severe

          Supplement interactions

          Pairs well with

          None listed.

          Avoid combining with

          No specific avoidances listed.

          Dosing & bioavailability

          Typical dose
          20–60 mg (≈600,000 IU)
          With food?
          Empty stomach

          Where to buy

          Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

          Compound
          Lumbrokinase
          Amazon
          Wide selection · fast shipping
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          Lumbrokinase
          iHerb
          Global delivery · curated brands
          Compound
          Lumbrokinase
          Thorne
          Practitioner-grade · NSF tested

          Scientific evidence (8)

          Meta-analysisEur Neurol · 2013

          Lumbrokinase in ischemic stroke

          Cao YJ, et al.

          Meta-analysis of 14 RCTs in acute ischemic stroke.

          Key findings

          Improved neurological scores vs control with acceptable bleeding profile.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Lumbrokinase — Improves outcomes in acute ischemic stroke

          Live PubMed search

          Live results for "Lumbrokinase Improves outcomes in acute ischemic stroke" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Lumbrokinase and "Improves outcomes in acute ischemic stroke". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Lumbrokinase — randomized controlled trial

          Live PubMed search

          Live results for "Lumbrokinase randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Lumbrokinase and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Lumbrokinase — meta-analysis

          Live PubMed search

          Live results for "Lumbrokinase meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Lumbrokinase and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Lumbrokinase — pharmacokinetics

          Live PubMed search

          Live results for "Lumbrokinase pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Lumbrokinase and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Lumbrokinase — safety adverse events

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          Live results for "Lumbrokinase safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Lumbrokinase and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Lumbrokinase — dose response

          Live PubMed search

          Live results for "Lumbrokinase dose response" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Lumbrokinase and "dose response". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewGoogle Scholar · 1970

          Google Scholar: Lumbrokinase — clinical evidence

          Live Scholar search

          Cross-database citation index for Lumbrokinase as it relates to "clinical evidence".

          Key findings

          Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

          Open study
          Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.