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Supplements/Compound

Psyllium Husk

Soluble fiber from Plantago ovata.

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Overview

Soluble fiber from Plantago ovata.

Natural sources
  • Endogenously produced or biosynthesized molecule
  • Standardized pharmaceutical- or food-grade supplement
  • Combined with cofactors that improve absorption or activity
Common forms
  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Mechanism of action

Forms gel that binds bile acids; bulks stool.

Pathways
  • · Forms gel that binds bile acids
  • · bulks stool

Effects on the body

Decreases
LDL, improves regularity

Organ system effects

Digestive / Gut

Psyllium Husk influences gut motility, mucosal integrity, or microbial balance in the GI tract.

Cardiovascular

Psyllium Husk supports endothelial function, lipid profile, or blood-pressure regulation in cardiovascular trials.

Evidence-based benefits

Lowers LDL, improves regularity

Moderate evidence

Potential side effects

Common
  • · Bloating
  • · Gas
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose Psyllium Husk use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Supplement interactions

      Pairs well with
      • Multi-strain probiotic
        Supports microbiome diversity and barrier integrity.
      • L-glutamine
        Substrate for enterocyte energy and tight-junction maintenance.
      • Omega-3
        Anti-inflammatory cardiovascular synergy.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      7–15 g
      Best form
      Most evidence is based on the capsule or softgel form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      With a meal containing fat for fat-soluble compounds; otherwise either.

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence8Show studies
      Meta-analysisAm J Clin Nutr · 2000

      Psyllium for cholesterol

      Anderson JW, et al.

      8 trials

      Key findings

      LDL reduction 7% at 10.2 g/d.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Psyllium Husk — Lowers LDL, improves regularity

      Live PubMed search

      Live results for "Psyllium Husk Lowers LDL, improves regularity" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Psyllium Husk and "Lowers LDL, improves regularity". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Psyllium Husk — randomized controlled trial

      Live PubMed search

      Live results for "Psyllium Husk randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Psyllium Husk and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Psyllium Husk — meta-analysis

      Live PubMed search

      Live results for "Psyllium Husk meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Psyllium Husk and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Psyllium Husk — pharmacokinetics

      Live PubMed search

      Live results for "Psyllium Husk pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Psyllium Husk and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Psyllium Husk — safety adverse events

      Live PubMed search

      Live results for "Psyllium Husk safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Psyllium Husk and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Psyllium Husk — dose response

      Live PubMed search

      Live results for "Psyllium Husk dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Psyllium Husk and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Psyllium Husk — clinical evidence

      Live Scholar search

      Cross-database citation index for Psyllium Husk as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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