Overview
Flushing form of B3 — historically used for dyslipidemia at gram doses.
- Whole-food sources (animal products for fat-soluble and B-complex vitamins; produce for water-soluble vitamins)
- Fortified foods (cereals, dairy, plant milks, nutritional yeast)
- Multivitamins or stand-alone supplements in synthetic or food-derived form
- Capsule or softgel
- Sublingual tablet or liquid
- Methylated active form for sensitive individuals
- Multivitamin matrix
Forms & variants of Niacin (Flush)
Different chemical forms of Niacin (Flush) behave differently. Browse each form's mechanism, bioavailability, and best-use context.
NAD+ precursor that bypasses the flush — studied for cellular aging.
Direct NAD+ precursor — popular longevity supplement with growing human data.
Non-flushing B3 — used for deficiency, skin health, and at high doses in dermatology.
Mechanism of action
Activates GPR109A on adipocytes → reduces FFA flux → lowers VLDL/triglycerides.
- · Activates GPR109A on adipocytes → reduces FFA flux → lowers VLDL/triglycerides
Effects on the body
Organ system effects
Niacin (Flush) supports endothelial function, lipid profile, or blood-pressure regulation in cardiovascular trials.
Evidence-based benefits
Raises HDL and lowers LDL/TG
Strong evidenceOutcome benefit unclear (AIM-HIGH/HPS2-THRIVE).
Potential side effects
- · Flushing
- · Itching
- · Headache
- · Hepatotoxicity (sustained-release)
- · Hyperglycemia
Drug interactions
Supplement interactions
- Omega-3Anti-inflammatory cardiovascular synergy.
- CoQ10Supports mitochondrial energetics in cardiac tissue.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.
Third-party testedIndependently verified Niacin (Flush) — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Niacin (Flush) third party tested NSF
CapsulesPre-measured Niacin (Flush) capsules — easiest for travel and consistent daily dosing without scoops or scales.Niacin (Flush) capsules
PowderBulk unflavored Niacin (Flush) powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Niacin (Flush) powder unflavored
Best sellersMost-purchased Niacin (Flush) products on Amazon — a quick way to see what's reviewed widely before you commit.Niacin (Flush) best sellerScientific evidence8Show studiesHide studies
Niacin on lipid profile (AIM-HIGH)
AIM-HIGH Investigators
RCT of niacin in patients on statin therapy.
Raised HDL but no incremental clinical benefit on statin.
PubMed: Niacin (Flush) — Raises HDL and lowers LDL/TG
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PubMed: Niacin (Flush) — randomized controlled trial
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PubMed: Niacin (Flush) — meta-analysis
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PubMed: Niacin (Flush) — dose response
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Google Scholar: Niacin (Flush) — clinical evidence
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Cross-database citation index for Niacin (Flush) as it relates to "clinical evidence".
Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.