SYS ONLINE
SUPPLEMENT_SCHOLAR
evidence · mechanism · dose
Supplements/Compound

NMN

aka Nicotinamide Mononucleotide

NAD+ precursor similar to NR; bioavailability route debated.

Healthy AgingEnergy Production

Overview

NAD+ precursor similar to NR; bioavailability route debated.

Natural sources
  • Trace in vegetables
Common forms
  • NMN powder/capsule

Mechanism of action

Direct precursor to NAD+ via NMNAT enzyme.

Pathways
  • · NAD+ salvage pathway

Effects on the body

Increases
NAD+ levels

Organ system effects

Skeletal Muscle

Improved aerobic capacity in older adults (Japanese trial).

Evidence-based benefits

Raises NAD+ in humans

Strong evidence

Modest physical capacity improvement (small trials)

Limited evidence

Potential side effects

Common
    Rare
      Serious

        Drug interactions

        No notable interactions reported.

        Supplement interactions

        Pairs well with

        None listed.

        Avoid combining with

        No specific avoidances listed.

        Dosing & bioavailability

        Typical dose
        250–500 mg/d

        Where to buy

        Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

        Compound
        NMN
        Amazon
        Wide selection · fast shipping
        Compound
        NMN
        iHerb
        Global delivery · curated brands
        Compound
        NMN
        Thorne
        Practitioner-grade · NSF tested

        Scientific evidence (9)

        RCTScience · 2021

        NMN on physiological function in older adults

        Yoshino M, et al.

        10-week RCT of NMN 250 mg in older women.

        Key findings

        Improved muscle insulin sensitivity and remodeling.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: NMN — Raises NAD+ in humans

        Live PubMed search

        Live results for "NMN Raises NAD+ in humans" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching NMN and "Raises NAD+ in humans". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: NMN — Modest physical capacity improvement

        Live PubMed search

        Live results for "NMN Modest physical capacity improvement" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching NMN and "Modest physical capacity improvement". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: NMN — randomized controlled trial

        Live PubMed search

        Live results for "NMN randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching NMN and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: NMN — meta-analysis

        Live PubMed search

        Live results for "NMN meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching NMN and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: NMN — pharmacokinetics

        Live PubMed search

        Live results for "NMN pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching NMN and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: NMN — safety adverse events

        Live PubMed search

        Live results for "NMN safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching NMN and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: NMN — dose response

        Live PubMed search

        Live results for "NMN dose response" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching NMN and "dose response". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewGoogle Scholar · 1970

        Google Scholar: NMN — clinical evidence

        Live Scholar search

        Cross-database citation index for NMN as it relates to "clinical evidence".

        Key findings

        Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

        Open study
        Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.