Energy Production
Mitochondrial output and perceived energy.
Ranked by evidence strength across reported benefits.
Coffee
Caffeine + polyphenol matrix with strong evidence for mortality and T2D reduction.
Vitamin B12
Essential cobalamin for methylation, red blood cell formation, and myelin maintenance.
Caffeine
Adenosine antagonist with strong evidence for cognitive and physical performance.
Hydroxocobalamin (B12)
Long-acting injectable form of B12 — used clinically for deficiency and cyanide poisoning.
Vitamin B1 (Thiamine)
Cofactor for carbohydrate metabolism and nerve conduction.
Vitamin B6 (Pyridoxine)
Cofactor for >100 enzymes including neurotransmitter synthesis.
Iron
Oxygen-carrying mineral central to hemoglobin and cellular respiration.
Beetroot Juice
Dietary nitrate source improving NO production, BP, and endurance performance.
Nicotinamide Riboside (NR)
NAD+ precursor with bioavailability and longevity research interest.
NMN
NAD+ precursor similar to NR; bioavailability route debated.
B-Complex (Drinking Recovery)
Alcohol depletes B1, B6, folate — repletion supports neurological recovery.
Methylcobalamin (B12)
Active methyl-form of B12 — directly usable in the methylation cycle.
Nicotinamide Riboside (NR)
NAD+ precursor that bypasses the flush — studied for cellular aging.
Modafinil (Rx note)
Wakefulness-promoting Rx — listed for reference; not a supplement.
Ferrous Sulfate
Standard low-cost iron salt — effective but commonly causes GI side effects.
Heme Iron Polypeptide
Animal-source heme iron — absorbed via separate receptor, unaffected by phytates/calcium.
Ubiquinone (CoQ10)
Standard oxidized CoQ10 — cheaper and effective in younger adults who can readily reduce it.
Coenzyme Q10
Mitochondrial electron carrier and lipid-soluble antioxidant.
L-Carnitine
Shuttles long-chain fatty acids into mitochondria for β-oxidation.
Maca
Andean root associated with libido improvement and energy without hormone changes.
Rhodiola Rosea
Arctic adaptogen — reduces fatigue and improves mental performance under stress.
Panax Ginseng
Adaptogenic ginseng studied for fatigue, cognition, and erectile function.
Ubiquinol (CoQ10)
Reduced active form of CoQ10 — preferred in adults over 40 and those with statin-induced depletion.
Taurine
Conditionally essential amino acid involved in bile salt conjugation, osmoregulation, and cardiac function.
Shilajit
Himalayan mineral exudate rich in fulvic acid, studied for testosterone and fatigue.
Maca (Lepidium meyenii)
Andean root traditionally used for libido and fertility — non-hormonal mechanism.
Rhodiola Rosea
Arctic adaptogen for mental fatigue, burnout, and stress resilience.
NMN (Nicotinamide Mononucleotide)
Direct NAD+ precursor — popular longevity supplement with growing human data.
L-Tyrosine (Dopamine Replenishment)
Catecholamine precursor — replenishes dopamine/norepinephrine pools after stimulant use.
Vitamin B2 (Riboflavin)
FAD/FMN precursor central to redox reactions and migraine prophylaxis.
L-Tyrosine
Catecholamine precursor preserving cognition under stress and sleep deprivation.
Schisandra
Adaptogenic berry traditionally used for stamina, liver protection, and stress resilience.
Cordyceps
Medicinal fungus studied for aerobic capacity and immune modulation.
L-Tyrosine (Thyroid Substrate)
Amino acid substrate paired with iodine to form thyroid hormones.
Panax Ginseng (Sexual Health)
Korean red ginseng with RCT-level evidence for erectile dysfunction.
Adenosylcobalamin (B12)
Mitochondrial coenzyme form of B12 — partners with methylcobalamin for full B12 status.
Riboflavin-5-Phosphate
Active form of B2 — used directly as FMN without liver conversion.
Iron Bisglycinate
Chelated ferrous iron — best-tolerated form with high absorption and minimal GI distress.
Sulbutiamine
Lipid-soluble thiamine derivative crossing the BBB for fatigue and focus.
Yerba Mate (Weight)
Polyphenol-caffeine extract used for appetite and energy.
P-Synephrine (Bitter Orange)
Bitter orange alkaloid used as ephedrine-replacement fat burner.
Cordyceps CS-4
Standardized cultivated cordyceps for kidney and energy support.
Yerba Mate (Focus)
Polyphenolic stimulant alternative to coffee for focus.
Panax Ginseng (Cognitive)
Asian ginseng (G115) studied for mental performance.
Rhodiola SHR-5 (Fatigue)
Adaptogen for stress-related fatigue and burnout.
Shilajit (Fulvic-Standardized)
Himalayan mineral pitch with fulvic acids studied for testosterone.
PQQ (Pyrroloquinoline Quinone)
Redox cofactor for mitochondrial biogenesis.
Cordyceps Militaris
Cordycepin-rich mushroom for energy and exercise.
Rhodiola SHR-5
Standardized Rhodiola for fatigue.
Suma Root
Brazilian ginseng adaptogen.
Black Maca
Lepidium meyenii black variant for energy.
Allithiamine
Garlic-derived fat-soluble thiamine.
Methylcobalamin High-Dose
Active B12 form for neuropathy.
Royal Jelly
Queen bee secretion with 10-HDA.
Bee Pollen
Pollen collected by bees.
Heme Iron Polypeptide
Heme iron from bovine blood.
Eleuthero
Adaptogen used to support stamina, immune function, and stress resilience.
Magnesium Malate
Magnesium + malic acid — favored for daytime energy and fibromyalgia-related fatigue.
Vitamin B5 (Pantothenic acid)
Component of coenzyme A, central to fatty acid and acetylcholine synthesis.
Yerba Mate
South American caffeine-containing tea with saponin and chlorogenic acid content.
PQQ
Cofactor stimulating mitochondrial biogenesis (PGC-1α).
Kratom (caution)
Atypical opioid herb with stimulant low-dose and sedating high-dose effects; addiction risk.
L-Ornithine
Urea-cycle amino acid that lowers fatigue and supports nighttime GH release.
Phenylpiracetam
Racetam + phenethylamine moiety — stimulant-like nootropic with rapid tolerance.
PQQ (Pyrroloquinoline Quinone)
Mitochondrial biogenesis cofactor — pairs with CoQ10 for energy production.