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Supplements/Nootropic

Phenylpiracetam

Racetam + phenethylamine moiety — stimulant-like nootropic with rapid tolerance.

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Overview

Racetam + phenethylamine moiety — stimulant-like nootropic with rapid tolerance.

Natural sources
  • Manufactured pharmaceutical-grade compound
  • Standardized botanical extract (for plant-derived nootropics)
  • Stack formulations combined with cholinergic or adaptogenic ingredients
Common forms
  • Capsule
  • Powder for stacking
  • Sublingual tablet
  • Liposomal liquid

Mechanism of action

Modulates D2 and NMDA; phenethylamine group adds mild adrenergic activity.

Pathways
  • · Modulates D2
  • · phenethylamine group adds mild adrenergic activity

Effects on the body

Supports
Cognitive and stimulant effects (Russian trials)

Organ system effects

Skeletal Muscle

Phenylpiracetam supports mitochondrial ATP production and fatigue resistance.

Evidence-based benefits

Cognitive and stimulant effects (Russian trials)

Limited evidence

Potential side effects

Common
  • · Tolerance within days
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose Phenylpiracetam use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid if you are
      • ·Pregnant or breastfeeding (insufficient safety data)
      • ·Children under 18 (unless directed by a clinician)

      Supplement interactions

      Pairs well with
      • A high-quality multivitamin
        Covers micronutrient cofactors that support most supplement pathways.
      • Omega-3 (EPA/DHA)
        Foundational anti-inflammatory support that complements most regimens.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      100–200 mg, not daily
      Best form
      Most evidence is based on the capsule form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      Optional

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence8Show studies
      RCTZh Nevrol Psikhiatr Im SS Korsakova · 2005

      Phenotropil in post-stroke cognitive function

      Savchenko AY, et al.

      RCT of phenylpiracetam in post-stroke patients.

      Key findings

      Improved cognition and daily-living scores.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Phenylpiracetam — Cognitive and stimulant effects

      Live PubMed search

      Live results for "Phenylpiracetam Cognitive and stimulant effects" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Phenylpiracetam and "Cognitive and stimulant effects". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Phenylpiracetam — randomized controlled trial

      Live PubMed search

      Live results for "Phenylpiracetam randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Phenylpiracetam and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Phenylpiracetam — meta-analysis

      Live PubMed search

      Live results for "Phenylpiracetam meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Phenylpiracetam and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Phenylpiracetam — pharmacokinetics

      Live PubMed search

      Live results for "Phenylpiracetam pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Phenylpiracetam and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Phenylpiracetam — safety adverse events

      Live PubMed search

      Live results for "Phenylpiracetam safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Phenylpiracetam and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Phenylpiracetam — dose response

      Live PubMed search

      Live results for "Phenylpiracetam dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Phenylpiracetam and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Phenylpiracetam — clinical evidence

      Live Scholar search

      Cross-database citation index for Phenylpiracetam as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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