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evidence · mechanism · dose
Supplements/Nootropic

Phenylpiracetam

Racetam + phenethylamine moiety — stimulant-like nootropic with rapid tolerance.

FocusCognitive PerformanceEnergy Production

Overview

Racetam + phenethylamine moiety — stimulant-like nootropic with rapid tolerance.

Natural sources
    Common forms

      Mechanism of action

      Modulates D2 and NMDA; phenethylamine group adds mild adrenergic activity.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Cognitive and stimulant effects (Russian trials)

        Limited evidence

        Potential side effects

        Common
        • · Tolerance within days
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            100–200 mg, not daily
            With food?
            Optional

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Nootropic
            Phenylpirace…
            Amazon
            Wide selection · fast shipping
            Nootropic
            Phenylpirace…
            iHerb
            Global delivery · curated brands
            Nootropic
            Phenylpirace…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTZh Nevrol Psikhiatr Im SS Korsakova · 2005

            Phenotropil in post-stroke cognitive function

            Savchenko AY, et al.

            RCT of phenylpiracetam in post-stroke patients.

            Key findings

            Improved cognition and daily-living scores.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Phenylpiracetam — Cognitive and stimulant effects

            Live PubMed search

            Live results for "Phenylpiracetam Cognitive and stimulant effects" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Phenylpiracetam and "Cognitive and stimulant effects". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Phenylpiracetam — randomized controlled trial

            Live PubMed search

            Live results for "Phenylpiracetam randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Phenylpiracetam and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Phenylpiracetam — meta-analysis

            Live PubMed search

            Live results for "Phenylpiracetam meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Phenylpiracetam and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Phenylpiracetam — pharmacokinetics

            Live PubMed search

            Live results for "Phenylpiracetam pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Phenylpiracetam and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Phenylpiracetam — safety adverse events

            Live PubMed search

            Live results for "Phenylpiracetam safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Phenylpiracetam and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Phenylpiracetam — dose response

            Live PubMed search

            Live results for "Phenylpiracetam dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Phenylpiracetam and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Phenylpiracetam — clinical evidence

            Live Scholar search

            Cross-database citation index for Phenylpiracetam as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.