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evidence · mechanism · dose
Supplements/Vitamin

Riboflavin-5-Phosphate

Active form of B2 — used directly as FMN without liver conversion.

Energy ProductionBrain & Cognitive

Overview

Active form of B2 — used directly as FMN without liver conversion.

Natural sources
    Common forms

      Forms & variants of Vitamin B2 (Riboflavin)

      Different chemical forms of Vitamin B2 (Riboflavin) behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Vitamin B2 (Riboflavin)

      FAD/FMN precursor central to redox reactions and migraine prophylaxis.

      Mechanism of action

      Direct FMN precursor for flavoprotein enzymes; cofactor for MTHFR.

      Pathways
      • · FMN/FAD redox
      • · MTHFR activation

      Effects on the body

      Organ system effects

      Evidence-based benefits

      Migraine prophylaxis (high-dose)

      Moderate evidence

      Potential side effects

      Common
      • · Bright yellow urine
      Rare
        Serious

          Drug interactions

          No notable interactions reported.

          Supplement interactions

          Pairs well with

          None listed.

          Avoid combining with

          No specific avoidances listed.

          Dosing & bioavailability

          Typical dose
          10–25 mg
          Study range
          400 mg for migraine
          With food?
          Optional

          Where to buy

          Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

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          Amazon
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          iHerb
          Global delivery · curated brands
          Vitamin
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          Thorne
          Practitioner-grade · NSF tested

          Scientific evidence (8)

          RCTNeurology · 1998

          Riboflavin for migraine prophylaxis

          Schoenen J, et al.

          3-month RCT of riboflavin 400 mg/d for migraine.

          Key findings

          Reduced migraine frequency by 50%.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Riboflavin-5-Phosphate — Migraine prophylaxis

          Live PubMed search

          Live results for "Riboflavin-5-Phosphate Migraine prophylaxis" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Riboflavin-5-Phosphate and "Migraine prophylaxis". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Riboflavin-5-Phosphate — randomized controlled trial

          Live PubMed search

          Live results for "Riboflavin-5-Phosphate randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Riboflavin-5-Phosphate and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Riboflavin-5-Phosphate — meta-analysis

          Live PubMed search

          Live results for "Riboflavin-5-Phosphate meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Riboflavin-5-Phosphate and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Riboflavin-5-Phosphate — pharmacokinetics

          Live PubMed search

          Live results for "Riboflavin-5-Phosphate pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Riboflavin-5-Phosphate and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Riboflavin-5-Phosphate — safety adverse events

          Live PubMed search

          Live results for "Riboflavin-5-Phosphate safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Riboflavin-5-Phosphate and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Riboflavin-5-Phosphate — dose response

          Live PubMed search

          Live results for "Riboflavin-5-Phosphate dose response" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Riboflavin-5-Phosphate and "dose response". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewGoogle Scholar · 1970

          Google Scholar: Riboflavin-5-Phosphate — clinical evidence

          Live Scholar search

          Cross-database citation index for Riboflavin-5-Phosphate as it relates to "clinical evidence".

          Key findings

          Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

          Open study
          Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.