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evidence · mechanism · dose
Supplements/Mineral

Heme Iron Polypeptide

Animal-source heme iron — absorbed via separate receptor, unaffected by phytates/calcium.

Energy ProductionGeneral Wellness

Overview

Animal-source heme iron — absorbed via separate receptor, unaffected by phytates/calcium.

Natural sources
    Common forms

      Forms & variants of Iron

      Different chemical forms of Iron behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Iron

      Oxygen-carrying mineral central to hemoglobin and cellular respiration.

      Bisglycinate
      Iron Bisglycinate

      Chelated ferrous iron — best-tolerated form with high absorption and minimal GI distress.

      Ferrous Sulfate
      Ferrous Sulfate

      Standard low-cost iron salt — effective but commonly causes GI side effects.

      Mechanism of action

      Absorbed intact via HCP1 receptor; ~25% bioavailability vs ~5–15% for non-heme.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Higher absorption than non-heme forms

        Strong evidence

        Potential side effects

        Common
          Rare
            Serious

              Drug interactions

              No notable interactions reported.

              Supplement interactions

              Pairs well with

              None listed.

              Avoid combining with

              No specific avoidances listed.

              Dosing & bioavailability

              Typical dose
              10–12 mg elemental
              With food?
              Optional

              Where to buy

              Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

              Mineral
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              Amazon
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              iHerb
              Global delivery · curated brands
              Mineral
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              Thorne
              Practitioner-grade · NSF tested

              Scientific evidence (8)

              RCTBr J Obstet Gynaecol · 1994

              Heme iron polypeptide vs ferrous sulfate

              Frykman E, et al.

              RCT in iron-deficient women.

              Key findings

              Comparable hemoglobin response with better tolerability.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Heme Iron Polypeptide — Higher absorption than non-heme forms

              Live PubMed search

              Live results for "Heme Iron Polypeptide Higher absorption than non-heme forms" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Heme Iron Polypeptide and "Higher absorption than non-heme forms". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Heme Iron Polypeptide — randomized controlled trial

              Live PubMed search

              Live results for "Heme Iron Polypeptide randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Heme Iron Polypeptide and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Heme Iron Polypeptide — meta-analysis

              Live PubMed search

              Live results for "Heme Iron Polypeptide meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Heme Iron Polypeptide and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Heme Iron Polypeptide — pharmacokinetics

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              Live results for "Heme Iron Polypeptide pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Heme Iron Polypeptide and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Heme Iron Polypeptide — safety adverse events

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              Live results for "Heme Iron Polypeptide safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

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              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Heme Iron Polypeptide — dose response

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              Live results for "Heme Iron Polypeptide dose response" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Heme Iron Polypeptide and "dose response". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewGoogle Scholar · 1970

              Google Scholar: Heme Iron Polypeptide — clinical evidence

              Live Scholar search

              Cross-database citation index for Heme Iron Polypeptide as it relates to "clinical evidence".

              Key findings

              Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

              Open study
              Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.