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Supplements/Amino Acid

L-Tyrosine (Dopamine Replenishment)

Catecholamine precursor — replenishes dopamine/norepinephrine pools after stimulant use.

Post-Drug Use RecoveryEnergy ProductionBrain & Cognitive

Overview

Catecholamine precursor — replenishes dopamine/norepinephrine pools after stimulant use.

Natural sources
    Common forms

      Mechanism of action

      Tyrosine → L-DOPA → dopamine → NE/Epi. Limited when tyrosine hydroxylase is downregulated.

      Pathways
      • · Catecholamine synthesis

      Effects on the body

      Organ system effects

      Evidence-based benefits

      Improves cognitive performance under acute stress

      Moderate evidence

      Reduces post-stimulant mood crash (anecdotal)

      Anecdotal

      Potential side effects

      Common
        Rare
          Serious

            Drug interactions

            MAOIs
            Hypertensive crisis risk.
            severe
            Levodopa
            May reduce levodopa absorption.
            moderate

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Other notes
            • ·Discuss with a clinician if you have active liver disease or take hepatotoxic medications.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            500–1500 mg AM, empty stomach
            Study range
            Up to 100 mg/kg acute
            With food?
            Empty stomach

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

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            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (9)

            Systematic reviewJ Psychiatr Res · 2015

            Tyrosine and cognitive performance under stress

            Jongkees BJ, et al.

            Review of tyrosine on cognition during stress/sleep loss.

            Key findings

            Improves working memory and flexibility under demanding conditions.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Tyrosine (Dopamine Replenishment) — Improves cognitive performance under acute stress

            Live PubMed search

            Live results for "L-Tyrosine (Dopamine Replenishment) Improves cognitive performance under acute stress" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Tyrosine (Dopamine Replenishment) and "Improves cognitive performance under acute stress". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Tyrosine (Dopamine Replenishment) — Reduces post-stimulant mood crash

            Live PubMed search

            Live results for "L-Tyrosine (Dopamine Replenishment) Reduces post-stimulant mood crash" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Tyrosine (Dopamine Replenishment) and "Reduces post-stimulant mood crash". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Tyrosine (Dopamine Replenishment) — randomized controlled trial

            Live PubMed search

            Live results for "L-Tyrosine (Dopamine Replenishment) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Tyrosine (Dopamine Replenishment) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Tyrosine (Dopamine Replenishment) — meta-analysis

            Live PubMed search

            Live results for "L-Tyrosine (Dopamine Replenishment) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Tyrosine (Dopamine Replenishment) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Tyrosine (Dopamine Replenishment) — pharmacokinetics

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            Live results for "L-Tyrosine (Dopamine Replenishment) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Tyrosine (Dopamine Replenishment) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Tyrosine (Dopamine Replenishment) — safety adverse events

            Live PubMed search

            Live results for "L-Tyrosine (Dopamine Replenishment) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

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            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: L-Tyrosine (Dopamine Replenishment) — dose response

            Live PubMed search

            Live results for "L-Tyrosine (Dopamine Replenishment) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching L-Tyrosine (Dopamine Replenishment) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: L-Tyrosine (Dopamine Replenishment) — clinical evidence

            Live Scholar search

            Cross-database citation index for L-Tyrosine (Dopamine Replenishment) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.