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evidence · mechanism · dose
Supplements/Compound

Glycine + NAC (GlyNAC)

Glutathione-boosting combination for aging.

Healthy Aging

Overview

Glutathione-boosting combination for aging.

Natural sources
    Common forms

      Mechanism of action

      Provides both rate-limiting precursors for glutathione synthesis.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves multiple aging markers

        Moderate evidence

        Potential side effects

        Common
        • · GI upset
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            100 mg/kg each

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
            Glycine + NA…
            Amazon
            Wide selection · fast shipping
            Compound
            Glycine + NA…
            iHerb
            Global delivery · curated brands
            Compound
            Glycine + NA…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTClin Transl Med · 2021

            GlyNAC in older adults

            Kumar P, et al.

            24 older adults

            Key findings

            Improved GSH, mitochondrial dysfunction, and physical function.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Glycine + NAC (GlyNAC) — Improves multiple aging markers

            Live PubMed search

            Live results for "Glycine + NAC (GlyNAC) Improves multiple aging markers" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Glycine + NAC (GlyNAC) and "Improves multiple aging markers". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Glycine + NAC (GlyNAC) — randomized controlled trial

            Live PubMed search

            Live results for "Glycine + NAC (GlyNAC) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Glycine + NAC (GlyNAC) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Glycine + NAC (GlyNAC) — meta-analysis

            Live PubMed search

            Live results for "Glycine + NAC (GlyNAC) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Glycine + NAC (GlyNAC) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Glycine + NAC (GlyNAC) — pharmacokinetics

            Live PubMed search

            Live results for "Glycine + NAC (GlyNAC) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Glycine + NAC (GlyNAC) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Glycine + NAC (GlyNAC) — safety adverse events

            Live PubMed search

            Live results for "Glycine + NAC (GlyNAC) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Glycine + NAC (GlyNAC) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Glycine + NAC (GlyNAC) — dose response

            Live PubMed search

            Live results for "Glycine + NAC (GlyNAC) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Glycine + NAC (GlyNAC) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Glycine + NAC (GlyNAC) — clinical evidence

            Live Scholar search

            Cross-database citation index for Glycine + NAC (GlyNAC) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.