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evidence · mechanism · dose
Supplements/Herb

Rhodiola SHR-5 (Fatigue)

Adaptogen for stress-related fatigue and burnout.

Energy ProductionBrain & Cognitive

Overview

Adaptogen for stress-related fatigue and burnout.

Natural sources
    Common forms

      Forms & variants of Rhodiola Rosea

      Different chemical forms of Rhodiola Rosea behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Rhodiola Rosea

      Arctic adaptogen — reduces fatigue and improves mental performance under stress.

      Mechanism of action

      Rosavin/salidroside modulate HPA axis and monoamine reuptake.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces fatigue scores in burnout

        Moderate evidence

        Potential side effects

        Common
        • · Insomnia if late
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            400 mg SHR-5
            With food?
            Morning

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Herb
            Rhodiola SHR…
            Amazon
            Wide selection · fast shipping
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            iHerb
            Global delivery · curated brands
            Herb
            Rhodiola SHR…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTPlanta Med · 2009

            Rhodiola in burnout

            Olsson EM, et al.

            28-day DB-RCT in 60 burnout patients.

            Key findings

            Reduced fatigue and improved cognitive performance vs placebo.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Rhodiola SHR-5 (Fatigue) — Reduces fatigue scores in burnout

            Live PubMed search

            Live results for "Rhodiola SHR-5 (Fatigue) Reduces fatigue scores in burnout" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Rhodiola SHR-5 (Fatigue) and "Reduces fatigue scores in burnout". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Rhodiola SHR-5 (Fatigue) — randomized controlled trial

            Live PubMed search

            Live results for "Rhodiola SHR-5 (Fatigue) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Rhodiola SHR-5 (Fatigue) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Rhodiola SHR-5 (Fatigue) — meta-analysis

            Live PubMed search

            Live results for "Rhodiola SHR-5 (Fatigue) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Rhodiola SHR-5 (Fatigue) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Rhodiola SHR-5 (Fatigue) — pharmacokinetics

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            Live results for "Rhodiola SHR-5 (Fatigue) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Rhodiola SHR-5 (Fatigue) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Rhodiola SHR-5 (Fatigue) — safety adverse events

            Live PubMed search

            Live results for "Rhodiola SHR-5 (Fatigue) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

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            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Rhodiola SHR-5 (Fatigue) — dose response

            Live PubMed search

            Live results for "Rhodiola SHR-5 (Fatigue) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Rhodiola SHR-5 (Fatigue) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Rhodiola SHR-5 (Fatigue) — clinical evidence

            Live Scholar search

            Cross-database citation index for Rhodiola SHR-5 (Fatigue) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.