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evidence · mechanism · dose
Supplements/Compound

Ubiquinone (CoQ10)

Standard oxidized CoQ10 — cheaper and effective in younger adults who can readily reduce it.

Cardiovascular HealthEnergy Production

Overview

Standard oxidized CoQ10 — cheaper and effective in younger adults who can readily reduce it.

Natural sources
    Common forms

      Forms & variants of Coenzyme Q10

      Different chemical forms of Coenzyme Q10 behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Coenzyme Q10

      Mitochondrial electron carrier and lipid-soluble antioxidant.

      Ubiquinol (reduced)
      Ubiquinol (CoQ10)

      Reduced active form of CoQ10 — preferred in adults over 40 and those with statin-induced depletion.

      Mechanism of action

      Body reduces ubiquinone → ubiquinol; reduction capacity declines with age.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Effective at raising plasma CoQ10 in <40y adults

        Strong evidence

        Potential side effects

        Common
          Rare
            Serious

              Drug interactions

              No notable interactions reported.

              Supplement interactions

              Pairs well with

              None listed.

              Avoid combining with

              No specific avoidances listed.

              Dosing & bioavailability

              Typical dose
              100–300 mg
              With food?
              With fat

              Where to buy

              Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

              Compound
              Ubiquinone (…
              Amazon
              Wide selection · fast shipping
              Compound
              Ubiquinone (…
              iHerb
              Global delivery · curated brands
              Compound
              Ubiquinone (…
              Thorne
              Practitioner-grade · NSF tested

              Scientific evidence (8)

              RCTJACC Heart Failure · 2014

              Ubiquinone in heart failure (Q-SYMBIO)

              Mortensen SA, et al.

              2-year RCT of ubiquinone 300 mg/d in CHF.

              Key findings

              43% reduction in cardiovascular mortality.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Ubiquinone (CoQ10) — Effective at raising plasma CoQ10 in <40y adults

              Live PubMed search

              Live results for "Ubiquinone (CoQ10) Effective at raising plasma CoQ10 in <40y adults" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Ubiquinone (CoQ10) and "Effective at raising plasma CoQ10 in <40y adults". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Ubiquinone (CoQ10) — randomized controlled trial

              Live PubMed search

              Live results for "Ubiquinone (CoQ10) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Ubiquinone (CoQ10) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Ubiquinone (CoQ10) — meta-analysis

              Live PubMed search

              Live results for "Ubiquinone (CoQ10) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Ubiquinone (CoQ10) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Ubiquinone (CoQ10) — pharmacokinetics

              Live PubMed search

              Live results for "Ubiquinone (CoQ10) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Ubiquinone (CoQ10) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Ubiquinone (CoQ10) — safety adverse events

              Live PubMed search

              Live results for "Ubiquinone (CoQ10) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Ubiquinone (CoQ10) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Ubiquinone (CoQ10) — dose response

              Live PubMed search

              Live results for "Ubiquinone (CoQ10) dose response" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Ubiquinone (CoQ10) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewGoogle Scholar · 1970

              Google Scholar: Ubiquinone (CoQ10) — clinical evidence

              Live Scholar search

              Cross-database citation index for Ubiquinone (CoQ10) as it relates to "clinical evidence".

              Key findings

              Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

              Open study
              Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.