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evidence · mechanism · dose
Supplements/Nootropic

Sulbutiamine

Lipid-soluble thiamine derivative crossing the BBB for fatigue and focus.

Brain & CognitiveEnergy Production

Overview

Lipid-soluble thiamine derivative crossing the BBB for fatigue and focus.

Natural sources
    Common forms

      Mechanism of action

      Increases central thiamine levels; modulates dopaminergic and glutamatergic transmission in prefrontal cortex.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces psychogenic asthenia

        Moderate evidence

        Potential side effects

        Common
        • · Headache
        • · Mild agitation
        Rare
        • · Mood swings with chronic use
        Serious

          Drug interactions

          No notable interactions reported.

          Safety & non-supplemental interactions

          Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

          Avoid if you are
          • ·Pregnant or breastfeeding (insufficient safety data)
          • ·Children under 18 (unless directed by a clinician)

          Supplement interactions

          Pairs well with

          None listed.

          Avoid combining with

          No specific avoidances listed.

          Dosing & bioavailability

          Typical dose
          200–600 mg
          With food?
          Morning

          Where to buy

          Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

          Nootropic
          Sulbutiamine
          Amazon
          Wide selection · fast shipping
          Nootropic
          Sulbutiamine
          iHerb
          Global delivery · curated brands
          Nootropic
          Sulbutiamine
          Thorne
          Practitioner-grade · NSF tested

          Scientific evidence (8)

          RCTLe Concours Medical · 1999

          Sulbutiamine in asthenia

          Tiev KP, et al.

          DB-RCT of 326 patients with chronic functional asthenia.

          Key findings

          Significant improvement vs placebo on asthenia scale at 4 weeks.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Sulbutiamine — Reduces psychogenic asthenia

          Live PubMed search

          Live results for "Sulbutiamine Reduces psychogenic asthenia" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Sulbutiamine and "Reduces psychogenic asthenia". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Sulbutiamine — randomized controlled trial

          Live PubMed search

          Live results for "Sulbutiamine randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Sulbutiamine and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Sulbutiamine — meta-analysis

          Live PubMed search

          Live results for "Sulbutiamine meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Sulbutiamine and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Sulbutiamine — pharmacokinetics

          Live PubMed search

          Live results for "Sulbutiamine pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Sulbutiamine and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Sulbutiamine — safety adverse events

          Live PubMed search

          Live results for "Sulbutiamine safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Sulbutiamine and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Sulbutiamine — dose response

          Live PubMed search

          Live results for "Sulbutiamine dose response" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Sulbutiamine and "dose response". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewGoogle Scholar · 1970

          Google Scholar: Sulbutiamine — clinical evidence

          Live Scholar search

          Cross-database citation index for Sulbutiamine as it relates to "clinical evidence".

          Key findings

          Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

          Open study
          Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.