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evidence · mechanism · dose
Supplements/Mushroom

Cordyceps CS-4

Standardized cultivated cordyceps for kidney and energy support.

Energy ProductionAthletic Performance

Overview

Standardized cultivated cordyceps for kidney and energy support.

Natural sources
    Common forms

      Forms & variants of Cordyceps

      Different chemical forms of Cordyceps behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Cordyceps

      Medicinal fungus studied for aerobic capacity and immune modulation.

      Mechanism of action

      Cordycepin and polysaccharides modulate AMPK and immune function.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves renal function in CKD trials

        Moderate evidence

        Potential side effects

        Common
          Rare
            Serious
            • · Possible bleeding risk

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            1–3 g CS-4
            With food?
            With food

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Mushroom
            Cordyceps CS-4
            Amazon
            Wide selection · fast shipping
            Mushroom
            Cordyceps CS-4
            iHerb
            Global delivery · curated brands
            Mushroom
            Cordyceps CS-4
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            Systematic reviewCochrane Database · 2014

            Cordyceps for CKD

            Zhang HW, et al.

            Cochrane review of cordyceps in CKD.

            Key findings

            Possible benefit on proteinuria; methodological limitations.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Cordyceps CS-4 — Improves renal function in CKD trials

            Live PubMed search

            Live results for "Cordyceps CS-4 Improves renal function in CKD trials" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Cordyceps CS-4 and "Improves renal function in CKD trials". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Cordyceps CS-4 — randomized controlled trial

            Live PubMed search

            Live results for "Cordyceps CS-4 randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Cordyceps CS-4 and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Cordyceps CS-4 — meta-analysis

            Live PubMed search

            Live results for "Cordyceps CS-4 meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Cordyceps CS-4 and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Cordyceps CS-4 — pharmacokinetics

            Live PubMed search

            Live results for "Cordyceps CS-4 pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Cordyceps CS-4 and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Cordyceps CS-4 — safety adverse events

            Live PubMed search

            Live results for "Cordyceps CS-4 safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Cordyceps CS-4 and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Cordyceps CS-4 — dose response

            Live PubMed search

            Live results for "Cordyceps CS-4 dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Cordyceps CS-4 and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Cordyceps CS-4 — clinical evidence

            Live Scholar search

            Cross-database citation index for Cordyceps CS-4 as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.