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evidence · mechanism · dose
Supplements/Vitamin

Methylcobalamin High-Dose

Active B12 form for neuropathy.

Brain & CognitiveEnergy Production

Overview

Active B12 form for neuropathy.

Natural sources
    Common forms

      Mechanism of action

      Methyl donor for methylation cycle.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reverses neuropathy

        Moderate evidence

        Potential side effects

        Common
        • · Acne
        • · Well tolerated
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            1500 mcg

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

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            Vitamin
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            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTClin Neurol Neurosurg · 1992

            Methylcobalamin in diabetic neuropathy

            Yaqub BA, et al.

            39 patients

            Key findings

            Improved nerve conduction.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Methylcobalamin High-Dose — Reverses neuropathy

            Live PubMed search

            Live results for "Methylcobalamin High-Dose Reverses neuropathy" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Methylcobalamin High-Dose and "Reverses neuropathy". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Methylcobalamin High-Dose — randomized controlled trial

            Live PubMed search

            Live results for "Methylcobalamin High-Dose randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Methylcobalamin High-Dose and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Methylcobalamin High-Dose — meta-analysis

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            Live results for "Methylcobalamin High-Dose meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Methylcobalamin High-Dose and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Methylcobalamin High-Dose — pharmacokinetics

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            Live results for "Methylcobalamin High-Dose pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Methylcobalamin High-Dose and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Methylcobalamin High-Dose — safety adverse events

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            Key findings

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            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Methylcobalamin High-Dose — dose response

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            Live results for "Methylcobalamin High-Dose dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Methylcobalamin High-Dose and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Methylcobalamin High-Dose — clinical evidence

            Live Scholar search

            Cross-database citation index for Methylcobalamin High-Dose as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.