Overview
Atypical opioid herb with stimulant low-dose and sedating high-dose effects; addiction risk.
- Mitragyna speciosa leaf
- Leaf powder
- Extract
Mechanism of action
Mitragynine partial agonist at mu-opioid receptor.
- · MOR partial agonism
- · Endorphins
Effects on the body
Organ system effects
Used (controversially) for opioid withdrawal.
Evidence-based benefits
Some evidence for opioid withdrawal/pain
Limited evidencePotential side effects
- · Nausea
- · Constipation
- · Dependence
- · Hepatotoxicity
- · Respiratory depression
Drug interactions
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Pregnant or breastfeeding (insufficient safety data)
- ·Children under 18 (unless directed by a clinician)
Supplement interactions
- A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
- Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.
- PregnancyNeonatal withdrawal.
- Polysubstance useMultiple deaths reported.
Dosing & bioavailability
Where to buy
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Kratom (Mitragyna speciosa) pharmacology and clinical effects
Prozialeck WC, et al.
Review of kratom use and adverse effects.
Opioid-like activity with dependence and hepatotoxicity risks.
PubMed: Kratom (caution) — Some evidence for opioid withdrawal/pain
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