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evidence · mechanism · dose
Supplements/Herb

Rhodiola SHR-5

Standardized Rhodiola for fatigue.

Energy ProductionMood & Anxiety

Overview

Standardized Rhodiola for fatigue.

Natural sources
    Common forms

      Mechanism of action

      Rosavins/salidroside modulate HPA and 5-HT.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces fatigue

        Moderate evidence

        Potential side effects

        Common
        • · Insomnia at high dose
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            200–400 mg

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Herb
            Rhodiola SHR-5
            Amazon
            Wide selection · fast shipping
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            Rhodiola SHR-5
            iHerb
            Global delivery · curated brands
            Herb
            Rhodiola SHR-5
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTPlanta Med · 2009

            Rhodiola in stress-related fatigue

            Olsson EM, et al.

            60 adults

            Key findings

            Reduced fatigue and improved attention.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Rhodiola SHR-5 — Reduces fatigue

            Live PubMed search

            Live results for "Rhodiola SHR-5 Reduces fatigue" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Rhodiola SHR-5 and "Reduces fatigue". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Rhodiola SHR-5 — randomized controlled trial

            Live PubMed search

            Live results for "Rhodiola SHR-5 randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Rhodiola SHR-5 and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Rhodiola SHR-5 — meta-analysis

            Live PubMed search

            Live results for "Rhodiola SHR-5 meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Rhodiola SHR-5 and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Rhodiola SHR-5 — pharmacokinetics

            Live PubMed search

            Live results for "Rhodiola SHR-5 pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Rhodiola SHR-5 and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Rhodiola SHR-5 — safety adverse events

            Live PubMed search

            Live results for "Rhodiola SHR-5 safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Rhodiola SHR-5 and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Rhodiola SHR-5 — dose response

            Live PubMed search

            Live results for "Rhodiola SHR-5 dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Rhodiola SHR-5 and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Rhodiola SHR-5 — clinical evidence

            Live Scholar search

            Cross-database citation index for Rhodiola SHR-5 as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.