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evidence · mechanism · dose
Supplements/Vitamin

Vitamin B5 (Pantothenic acid)

Component of coenzyme A, central to fatty acid and acetylcholine synthesis.

Skin, Hair & NailsEnergy ProductionGeneral Wellness

Overview

Component of coenzyme A, central to fatty acid and acetylcholine synthesis.

Natural sources
  • Almost all foods
  • Liver
  • Egg yolk
Common forms
  • Calcium pantothenate
  • Pantethine

Mechanism of action

Forms coenzyme A and acyl-carrier protein, required for fatty acid synthesis and citric acid cycle.

Pathways
  • · CoA synthesis
  • · Fatty acid oxidation

Effects on the body

Supports
Coenzyme A pools

Organ system effects

Skin

Pantothenol used topically as humectant.

Evidence-based benefits

Pantethine modestly lowers LDL/TG

Limited evidence

Potential side effects

Common
    Rare
    • · Diarrhea at multi-gram doses
    Serious

      Drug interactions

      No notable interactions reported.

      Supplement interactions

      Pairs well with

      None listed.

      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      5 mg general; 600–1200 mg pantethine for lipids

      Where to buy

      Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

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      Practitioner-grade · NSF tested

      Scientific evidence (8)

      Systematic reviewExamine.com Supplement Database · 2023

      Vitamin B5 (Pantothenic acid): pharmacology, clinical evidence, and safety — narrative review

      Examine.com Research Team

      Curated narrative review of human and preclinical evidence for Vitamin B5 (Pantothenic acid), including mechanism, typical dosing, and safety considerations.

      Key findings

      Best-supported outcome: Pantethine modestly lowers LDL/TG (evidence: limited). Additional outcomes and limitations summarized in the full profile.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Vitamin B5 (Pantothenic acid) — Pantethine modestly lowers LDL/TG

      Live PubMed search

      Live results for "Vitamin B5 (Pantothenic acid) Pantethine modestly lowers LDL/TG" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Vitamin B5 (Pantothenic acid) and "Pantethine modestly lowers LDL/TG". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Vitamin B5 (Pantothenic acid) — randomized controlled trial

      Live PubMed search

      Live results for "Vitamin B5 (Pantothenic acid) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Vitamin B5 (Pantothenic acid) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Vitamin B5 (Pantothenic acid) — meta-analysis

      Live PubMed search

      Live results for "Vitamin B5 (Pantothenic acid) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Vitamin B5 (Pantothenic acid) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Vitamin B5 (Pantothenic acid) — pharmacokinetics

      Live PubMed search

      Live results for "Vitamin B5 (Pantothenic acid) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Vitamin B5 (Pantothenic acid) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Vitamin B5 (Pantothenic acid) — safety adverse events

      Live PubMed search

      Live results for "Vitamin B5 (Pantothenic acid) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Vitamin B5 (Pantothenic acid) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Vitamin B5 (Pantothenic acid) — dose response

      Live PubMed search

      Live results for "Vitamin B5 (Pantothenic acid) dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Vitamin B5 (Pantothenic acid) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Vitamin B5 (Pantothenic acid) — clinical evidence

      Live Scholar search

      Cross-database citation index for Vitamin B5 (Pantothenic acid) as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.