Overview
Component of coenzyme A, central to fatty acid and acetylcholine synthesis.
- Almost all foods
- Liver
- Egg yolk
- Calcium pantothenate
- Pantethine
Mechanism of action
Forms coenzyme A and acyl-carrier protein, required for fatty acid synthesis and citric acid cycle.
- · CoA synthesis
- · Fatty acid oxidation
Effects on the body
Organ system effects
Pantothenol used topically as humectant.
Evidence-based benefits
Pantethine modestly lowers LDL/TG
Limited evidencePotential side effects
- · Diarrhea at multi-gram doses
Drug interactions
Supplement interactions
- Collagen peptidesProvides amino acid substrate for connective tissue synthesis.
- Vitamin CRequired cofactor for collagen hydroxylation.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Vitamin B5 (Pantothenic acid): pharmacology, clinical evidence, and safety — narrative review
Examine.com Research Team
Curated narrative review of human and preclinical evidence for Vitamin B5 (Pantothenic acid), including mechanism, typical dosing, and safety considerations.
Best-supported outcome: Pantethine modestly lowers LDL/TG (evidence: limited). Additional outcomes and limitations summarized in the full profile.
PubMed: Vitamin B5 (Pantothenic acid) — Pantethine modestly lowers LDL/TG
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PubMed: Vitamin B5 (Pantothenic acid) — randomized controlled trial
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PubMed: Vitamin B5 (Pantothenic acid) — dose response
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Google Scholar: Vitamin B5 (Pantothenic acid) — clinical evidence
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