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Supplements/Compound

Royal Jelly

Queen bee secretion with 10-HDA.

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Overview

Queen bee secretion with 10-HDA.

Natural sources
  • Endogenously produced or biosynthesized molecule
  • Standardized pharmaceutical- or food-grade supplement
  • Combined with cofactors that improve absorption or activity
Common forms
  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Mechanism of action

10-HDA has estrogenic and neurotrophic effects.

Pathways
  • · 10-HDA has estrogenic
  • · neurotrophic effects

Effects on the body

Supports
May improve menopausal symptoms

Organ system effects

Skeletal Muscle

Royal Jelly supports mitochondrial ATP production and fatigue resistance.

Reproductive

Royal Jelly has documented effects on female reproductive endocrinology and cycle regulation.

Evidence-based benefits

May improve menopausal symptoms

Moderate evidence

Potential side effects

Common
  • · Allergy
  • · Asthma
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose Royal Jelly use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Supplement interactions

      Pairs well with
      • A high-quality multivitamin
        Covers micronutrient cofactors that support most supplement pathways.
      • Omega-3 (EPA/DHA)
        Foundational anti-inflammatory support that complements most regimens.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      500–1500 mg
      Best form
      Most evidence is based on the capsule or softgel form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      With a meal containing fat for fat-soluble compounds; otherwise either.

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence8Show studies
      RCTClimacteric · 2018

      Royal jelly for menopause

      Asama T, et al.

      42 women

      Key findings

      Reduced menopausal symptoms.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Royal Jelly — May improve menopausal symptoms

      Live PubMed search

      Live results for "Royal Jelly May improve menopausal symptoms" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Royal Jelly and "May improve menopausal symptoms". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Royal Jelly — randomized controlled trial

      Live PubMed search

      Live results for "Royal Jelly randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Royal Jelly and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Royal Jelly — meta-analysis

      Live PubMed search

      Live results for "Royal Jelly meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Royal Jelly and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Royal Jelly — pharmacokinetics

      Live PubMed search

      Live results for "Royal Jelly pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Royal Jelly and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Royal Jelly — safety adverse events

      Live PubMed search

      Live results for "Royal Jelly safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Royal Jelly and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Royal Jelly — dose response

      Live PubMed search

      Live results for "Royal Jelly dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Royal Jelly and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Royal Jelly — clinical evidence

      Live Scholar search

      Cross-database citation index for Royal Jelly as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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