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Heme Iron Polypeptide

Heme iron from bovine blood.

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Overview

Heme iron from bovine blood.

Natural sources
  • Whole foods (leafy greens, legumes, nuts, seeds, seafood, animal proteins)
  • Fortified foods such as cereals, breads, plant milks, and table salt
  • Mineral supplements as chelates, citrates, glycinates, or inorganic salts
Common forms
  • Chelated form (glycinate, bisglycinate, citrate, malate)
  • Inorganic salt (oxide, sulfate, chloride)
  • Liquid ionic solution
  • Topical or transdermal preparation

Mechanism of action

Absorbed via heme transporter.

Pathways
  • · Absorbed via heme transporter

Effects on the body

Supports
High bioavailability

Organ system effects

Skeletal Muscle

Heme Iron Polypeptide supports mitochondrial ATP production and fatigue resistance.

Evidence-based benefits

High bioavailability

Moderate evidence

Potential side effects

Common
  • · Well tolerated
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose Heme Iron Polypeptide use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Supplement interactions

      Pairs well with
      • A high-quality multivitamin
        Covers micronutrient cofactors that support most supplement pathways.
      • Omega-3 (EPA/DHA)
        Foundational anti-inflammatory support that complements most regimens.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      11 mg
      Best form
      Most evidence is based on the chelated form (glycinate, bisglycinate, citrate, malate) form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      Either with or without food.

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence8Show studies
      Systematic reviewAm J Kidney Dis · 2003

      Heme iron for anemia

      Nissenson AR, et al.

      Clinical review

      Key findings

      Effective for iron deficiency.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Heme Iron Polypeptide — High bioavailability

      Live PubMed search

      Live results for "Heme Iron Polypeptide High bioavailability" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Heme Iron Polypeptide and "High bioavailability". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Heme Iron Polypeptide — randomized controlled trial

      Live PubMed search

      Live results for "Heme Iron Polypeptide randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Heme Iron Polypeptide and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Heme Iron Polypeptide — meta-analysis

      Live PubMed search

      Live results for "Heme Iron Polypeptide meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Heme Iron Polypeptide and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Heme Iron Polypeptide — pharmacokinetics

      Live PubMed search

      Live results for "Heme Iron Polypeptide pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Heme Iron Polypeptide and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Heme Iron Polypeptide — safety adverse events

      Live PubMed search

      Live results for "Heme Iron Polypeptide safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Heme Iron Polypeptide and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Heme Iron Polypeptide — dose response

      Live PubMed search

      Live results for "Heme Iron Polypeptide dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Heme Iron Polypeptide and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Heme Iron Polypeptide — clinical evidence

      Live Scholar search

      Cross-database citation index for Heme Iron Polypeptide as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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