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evidence · mechanism · dose
Supplements/Herb

Yerba Mate (Weight)

Polyphenol-caffeine extract used for appetite and energy.

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Energy Production

Overview

Polyphenol-caffeine extract used for appetite and energy.

Natural sources
  • Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)
  • Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)
  • Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice
Common forms
  • Standardized extract capsule
  • Liquid tincture (alcohol or glycerin)
  • Powdered whole herb
  • Traditional decoction or tea

Forms & variants of Yerba Mate

Different chemical forms of Yerba Mate behave differently. Browse each form's mechanism, bioavailability, and best-use context.

Parent
Yerba Mate

South American caffeine-containing tea with saponin and chlorogenic acid content.

Focus dose
Yerba Mate (Focus)

Polyphenolic stimulant alternative to coffee for focus.

Mechanism of action

Caffeine + chlorogenic acids enhance fat oxidation and reduce appetite via GLP-1.

Pathways
  • · Caffeine + chlorogenic acids enhance fat oxidation
  • · reduce appetite via GLP-1

Effects on the body

Decreases
body fat over 12 weeks

Organ system effects

Skeletal Muscle

Yerba Mate (Weight) supports mitochondrial ATP production and fatigue resistance.

Evidence-based benefits

Reduces body fat over 12 weeks

Moderate evidence

Potential side effects

Common
  • · Jitter
  • · Insomnia
Rare
    Serious
    • · Possible esophageal cancer risk with hot drinking long-term

    Drug interactions

    Prescription medications (general)
    Always disclose Yerba Mate (Weight) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
    minor

    Safety & non-supplemental interactions

    Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

    Avoid if you are
    • ·Pregnant or breastfeeding (insufficient safety data)
    • ·Children under 18 (unless directed by a clinician)

    Supplement interactions

    Pairs well with
    • A high-quality multivitamin
      Covers micronutrient cofactors that support most supplement pathways.
    • Omega-3 (EPA/DHA)
      Foundational anti-inflammatory support that complements most regimens.
    Avoid combining with

    No specific avoidances listed.

    Dosing & bioavailability

    Typical dose
    1000 mg extract tid
    Best form
    Most evidence is based on the standardized extract capsule form.
    Timing
    Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
    With food?
    Before meals

    Where to buy

    Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

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    Scientific evidence8Show studies
    RCTBMC Complement Altern Med · 2015

    Yerba mate for weight loss

    Kim SY, et al.

    12-week DB-RCT in 30 obese adults.

    Key findings

    Reduced body fat % and waist-to-hip ratio vs placebo.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Yerba Mate (Weight) — Reduces body fat over 12 weeks

    Live PubMed search

    Live results for "Yerba Mate (Weight) Reduces body fat over 12 weeks" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Yerba Mate (Weight) and "Reduces body fat over 12 weeks". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Yerba Mate (Weight) — randomized controlled trial

    Live PubMed search

    Live results for "Yerba Mate (Weight) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Yerba Mate (Weight) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Yerba Mate (Weight) — meta-analysis

    Live PubMed search

    Live results for "Yerba Mate (Weight) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Yerba Mate (Weight) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Yerba Mate (Weight) — pharmacokinetics

    Live PubMed search

    Live results for "Yerba Mate (Weight) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Yerba Mate (Weight) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Yerba Mate (Weight) — safety adverse events

    Live PubMed search

    Live results for "Yerba Mate (Weight) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Yerba Mate (Weight) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Yerba Mate (Weight) — dose response

    Live PubMed search

    Live results for "Yerba Mate (Weight) dose response" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Yerba Mate (Weight) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewGoogle Scholar · 1970

    Google Scholar: Yerba Mate (Weight) — clinical evidence

    Live Scholar search

    Cross-database citation index for Yerba Mate (Weight) as it relates to "clinical evidence".

    Key findings

    Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

    Open study
    Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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