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Supplements/Herb

Rhodiola Rosea

Arctic adaptogen for mental fatigue, burnout, and stress resilience.

Energy ProductionMental ClarityStress RecoveryDepression SupportCortisol Management (alias)

Overview

Arctic adaptogen for mental fatigue, burnout, and stress resilience.

Natural sources
    Common forms

      Mechanism of action

      Rosavins and salidrosides modulate serotonin/dopamine and HPA-axis.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces mental fatigue in burnout

        Moderate evidence

        Mild antidepressant

        Limited evidence

        Potential side effects

        Common
        • · Insomnia (if late)
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            200–400 mg standardized to 3% rosavins
            With food?
            Morning

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Herb
            Rhodiola Rosea
            Amazon
            Wide selection · fast shipping
            Herb
            Rhodiola Rosea
            iHerb
            Global delivery · curated brands
            Herb
            Rhodiola Rosea
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (9)

            Meta-analysisPhytomedicine · 2011

            Rhodiola rosea for fatigue: a meta-analysis

            Hung SK, et al.

            Meta-analysis of Rhodiola for mental/physical fatigue.

            Key findings

            Significant reduction in fatigue and improved performance.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Rhodiola Rosea — Reduces mental fatigue in burnout

            Live PubMed search

            Live results for "Rhodiola Rosea Reduces mental fatigue in burnout" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Rhodiola Rosea and "Reduces mental fatigue in burnout". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Rhodiola Rosea — Mild antidepressant

            Live PubMed search

            Live results for "Rhodiola Rosea Mild antidepressant" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Rhodiola Rosea and "Mild antidepressant". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Rhodiola Rosea — randomized controlled trial

            Live PubMed search

            Live results for "Rhodiola Rosea randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Rhodiola Rosea and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Rhodiola Rosea — meta-analysis

            Live PubMed search

            Live results for "Rhodiola Rosea meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Rhodiola Rosea and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Rhodiola Rosea — pharmacokinetics

            Live PubMed search

            Live results for "Rhodiola Rosea pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Rhodiola Rosea and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Rhodiola Rosea — safety adverse events

            Live PubMed search

            Live results for "Rhodiola Rosea safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Rhodiola Rosea and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Rhodiola Rosea — dose response

            Live PubMed search

            Live results for "Rhodiola Rosea dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Rhodiola Rosea and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Rhodiola Rosea — clinical evidence

            Live Scholar search

            Cross-database citation index for Rhodiola Rosea as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.