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evidence · mechanism · dose
Supplements/Compound

Modafinil (Rx note)

Wakefulness-promoting Rx — listed for reference; not a supplement.

Brain & CognitiveEnergy Production

Overview

Wakefulness-promoting Rx — listed for reference; not a supplement.

Natural sources
  • Prescription only
Common forms
  • Rx tablet

Mechanism of action

Weakly inhibits DAT; activates orexin and histamine.

Pathways
  • · DAT inhibition
  • · Orexin

Effects on the body

Increases
Wakefulness

Organ system effects

Brain & CNS

Approved for narcolepsy and shift work sleep disorder.

Evidence-based benefits

Reduces excessive sleepiness

Strong evidence

Potential side effects

Common
  • · Headache
  • · Nausea
Rare
    Serious
    • · Stevens-Johnson syndrome (rare)

    Drug interactions

    Hormonal contraceptives
    CYP3A4 induction reduces efficacy.
    severe

    Supplement interactions

    Pairs well with

    None listed.

    Avoid combining with
    • Self-medication
      Prescription-only — consult physician.

    Dosing & bioavailability

    Typical dose
    Rx 100–200 mg morning

    Where to buy

    Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

    Compound
    Modafinil (R…
    Amazon
    Wide selection · fast shipping
    Compound
    Modafinil (R…
    iHerb
    Global delivery · curated brands
    Compound
    Modafinil (R…
    Thorne
    Practitioner-grade · NSF tested

    Scientific evidence (8)

    Systematic reviewEur Neuropsychopharmacol · 2015

    Adrafinil/modafinil for fatigue and cognition

    Battleday RM, Brem AK

    Review of modafinil-class cognitive effects.

    Key findings

    Consistent enhancement of attention and executive function.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Modafinil (Rx note) — Reduces excessive sleepiness

    Live PubMed search

    Live results for "Modafinil (Rx note) Reduces excessive sleepiness" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Modafinil (Rx note) and "Reduces excessive sleepiness". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Modafinil (Rx note) — randomized controlled trial

    Live PubMed search

    Live results for "Modafinil (Rx note) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Modafinil (Rx note) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Modafinil (Rx note) — meta-analysis

    Live PubMed search

    Live results for "Modafinil (Rx note) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Modafinil (Rx note) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Modafinil (Rx note) — pharmacokinetics

    Live PubMed search

    Live results for "Modafinil (Rx note) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Modafinil (Rx note) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Modafinil (Rx note) — safety adverse events

    Live PubMed search

    Live results for "Modafinil (Rx note) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Modafinil (Rx note) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Modafinil (Rx note) — dose response

    Live PubMed search

    Live results for "Modafinil (Rx note) dose response" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Modafinil (Rx note) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewGoogle Scholar · 1970

    Google Scholar: Modafinil (Rx note) — clinical evidence

    Live Scholar search

    Cross-database citation index for Modafinil (Rx note) as it relates to "clinical evidence".

    Key findings

    Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

    Open study
    Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.