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evidence · mechanism · dose
Supplements/Vitamin

Niacinamide

Non-flushing B3 — used for deficiency, skin health, and at high doses in dermatology.

Skin, Hair & NailsGeneral Wellness

Overview

Non-flushing B3 — used for deficiency, skin health, and at high doses in dermatology.

Natural sources
    Common forms

      Forms & variants of Niacinamide

      Different chemical forms of Niacinamide behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Nicotinamide Riboside
      Nicotinamide Riboside (NR)

      NAD+ precursor that bypasses the flush — studied for cellular aging.

      NMN
      NMN (Nicotinamide Mononucleotide)

      Direct NAD+ precursor — popular longevity supplement with growing human data.

      Nicotinic Acid
      Niacin (Flush)

      Flushing form of B3 — historically used for dyslipidemia at gram doses.

      Mechanism of action

      Direct NAD+ precursor (does not affect lipids like niacin).

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces non-melanoma skin cancer recurrence

        Moderate evidence

        Improves rosacea/acne

        Limited evidence

        Potential side effects

        Common
          Rare
          • · Liver enzyme elevation at >3 g/d
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            16 mg RDA; 500 mg BID for skin cancer prevention
            With food?
            Optional

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Vitamin
            Niacinamide
            Amazon
            Wide selection · fast shipping
            Vitamin
            Niacinamide
            iHerb
            Global delivery · curated brands
            Vitamin
            Niacinamide
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (9)

            RCTDermatol Surg · 2005

            Niacinamide and skin barrier function

            Bissett DL, et al.

            12-week RCT of topical niacinamide 5%.

            Key findings

            Reduced hyperpigmentation, fine lines, and red blotchiness.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Niacinamide — Reduces non-melanoma skin cancer recurrence

            Live PubMed search

            Live results for "Niacinamide Reduces non-melanoma skin cancer recurrence" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Niacinamide and "Reduces non-melanoma skin cancer recurrence". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Niacinamide — Improves rosacea/acne

            Live PubMed search

            Live results for "Niacinamide Improves rosacea/acne" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Niacinamide and "Improves rosacea/acne". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Niacinamide — randomized controlled trial

            Live PubMed search

            Live results for "Niacinamide randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Niacinamide and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Niacinamide — meta-analysis

            Live PubMed search

            Live results for "Niacinamide meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Niacinamide and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Niacinamide — pharmacokinetics

            Live PubMed search

            Live results for "Niacinamide pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Niacinamide and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Niacinamide — safety adverse events

            Live PubMed search

            Live results for "Niacinamide safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Niacinamide and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Niacinamide — dose response

            Live PubMed search

            Live results for "Niacinamide dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Niacinamide and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Niacinamide — clinical evidence

            Live Scholar search

            Cross-database citation index for Niacinamide as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.