Overview
French maritime pine bark for circulation.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Procyanidins; NO synthase enhancer.
- · Procyanidins
- · NO synthase enhancer
Effects on the body
Organ system effects
Pycnogenol (Pine Bark) supports endothelial function, lipid profile, or blood-pressure regulation in cardiovascular trials.
Pycnogenol (Pine Bark) acts on central nervous system targets implicated in attention, memory, and neuroprotection.
Evidence-based benefits
Improves endothelial function
Moderate evidencePotential side effects
- · GI upset
Drug interactions
Supplement interactions
- Omega-3Anti-inflammatory cardiovascular synergy.
- CoQ10Supports mitochondrial energetics in cardiac tissue.
- Omega-3 (EPA/DHA)Membrane fluidity and neuronal signaling support.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Pycnogenol (Pine Bark) — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Pycnogenol (Pine Bark) third party tested NSF
CapsulesPre-measured Pycnogenol (Pine Bark) capsules — easiest for travel and consistent daily dosing without scoops or scales.Pycnogenol (Pine Bark) capsules
PowderBulk unflavored Pycnogenol (Pine Bark) powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Pycnogenol (Pine Bark) powder unflavored
Best sellersMost-purchased Pycnogenol (Pine Bark) products on Amazon — a quick way to see what's reviewed widely before you commit.Pycnogenol (Pine Bark) best sellerScientific evidence8Show studiesHide studies
Pycnogenol for hypertension
Liu X, et al.
58 mild hypertensives
Reduced systolic BP.
PubMed: Pycnogenol (Pine Bark) — Improves endothelial function
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