SYS ONLINE
SUPPLEMENT_SCHOLAR
evidence · mechanism · dose
Supplements/Fatty Acid

Black Seed Oil (Nigella sativa)

Thymoquinone for immune and metabolic health.

Immune FunctionCardiovascular Health

Overview

Thymoquinone for immune and metabolic health.

Natural sources
    Common forms

      Mechanism of action

      Thymoquinone is antioxidant and anti-inflammatory.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves glucose and lipids

        Moderate evidence

        Potential side effects

        Common
        • · GI upset
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid with these conditions
            • ·Autoimmune disease (theoretical immune activation)
            Avoid / monitor with these medications
            • ·Immunosuppressants

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            1–3 g

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Fatty Acid
            Black Seed O…
            Amazon
            Wide selection · fast shipping
            Fatty Acid
            Black Seed O…
            iHerb
            Global delivery · curated brands
            Fatty Acid
            Black Seed O…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            Meta-analysisPharmacol Res · 2016

            Nigella sativa meta-analysis

            Sahebkar A, et al.

            17 RCTs

            Key findings

            Improved glycemic and lipid profiles.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Black Seed Oil (Nigella sativa) — Improves glucose and lipids

            Live PubMed search

            Live results for "Black Seed Oil (Nigella sativa) Improves glucose and lipids" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Black Seed Oil (Nigella sativa) and "Improves glucose and lipids". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Black Seed Oil (Nigella sativa) — randomized controlled trial

            Live PubMed search

            Live results for "Black Seed Oil (Nigella sativa) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Black Seed Oil (Nigella sativa) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Black Seed Oil (Nigella sativa) — meta-analysis

            Live PubMed search

            Live results for "Black Seed Oil (Nigella sativa) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Black Seed Oil (Nigella sativa) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Black Seed Oil (Nigella sativa) — pharmacokinetics

            Live PubMed search

            Live results for "Black Seed Oil (Nigella sativa) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Black Seed Oil (Nigella sativa) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Black Seed Oil (Nigella sativa) — safety adverse events

            Live PubMed search

            Live results for "Black Seed Oil (Nigella sativa) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Black Seed Oil (Nigella sativa) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Black Seed Oil (Nigella sativa) — dose response

            Live PubMed search

            Live results for "Black Seed Oil (Nigella sativa) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Black Seed Oil (Nigella sativa) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Black Seed Oil (Nigella sativa) — clinical evidence

            Live Scholar search

            Cross-database citation index for Black Seed Oil (Nigella sativa) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.