Overview
Standardized citrus polyphenol fraction shown to lower LDL and triglycerides.
- Citrus bergamia
- Bergamot Polyphenolic Fraction (BPF)
Mechanism of action
Polyphenols inhibit HMG-CoA reductase and increase LDL receptor expression.
- · HMG-CoA inhibition
- · LDLR upregulation
Effects on the body
Organ system effects
Adjunct or alternative for mild dyslipidemia.
Evidence-based benefits
Reduces LDL & TG, raises HDL
Moderate evidencePotential side effects
- · Bergamot Extract is generally well-tolerated at evidence-based doses
- · Mild GI discomfort (nausea, loose stools, or bloating) possible at higher intakes
- · Headache or transient fatigue reported by a small fraction of users
- · Allergic or hypersensitivity reaction (rash, itching, swelling)
- · Sleep disturbance if taken late in the day
- · Discontinue and seek medical advice if symptoms are severe, persistent, or include difficulty breathing
Drug interactions
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Pregnant or breastfeeding (insufficient safety data)
- ·Children under 18 (unless directed by a clinician)
- ·Bleeding disorders
- ·Warfarin, DOACs, antiplatelets, NSAIDs (additive bleeding risk)
- ·Discuss stopping ≥2 weeks before scheduled surgery.
Supplement interactions
- Omega-3Anti-inflammatory cardiovascular synergy.
- CoQ10Supports mitochondrial energetics in cardiac tissue.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.
Third-party testedIndependently verified Bergamot Extract — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Bergamot Extract third party tested NSF
CapsulesPre-measured Bergamot Extract capsules — easiest for travel and consistent daily dosing without scoops or scales.Bergamot Extract capsules
PowderBulk unflavored Bergamot Extract powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Bergamot Extract powder unflavored
Best sellersMost-purchased Bergamot Extract products on Amazon — a quick way to see what's reviewed widely before you commit.Bergamot Extract best sellerScientific evidence8Show studiesHide studies
Bergamot polyphenolic fraction on dyslipidemia and metabolic syndrome
Mollace V, et al.
30-day RCT of BPF in dyslipidemic patients.
Significant reductions in LDL-C, triglycerides, and blood glucose.
PubMed: Bergamot Extract — Reduces LDL & TG, raises HDL
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PubMed: Bergamot Extract — randomized controlled trial
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PubMed: Bergamot Extract — dose response
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