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evidence · mechanism · dose
Supplements/Herb

Bergamot Extract

aka Citrus bergamia

Standardized citrus polyphenol fraction shown to lower LDL and triglycerides.

Cardiovascular Health

Overview

Standardized citrus polyphenol fraction shown to lower LDL and triglycerides.

Natural sources
  • Citrus bergamia
Common forms
  • Bergamot Polyphenolic Fraction (BPF)

Mechanism of action

Polyphenols inhibit HMG-CoA reductase and increase LDL receptor expression.

Pathways
  • · HMG-CoA inhibition
  • · LDLR upregulation

Effects on the body

Decreases
LDL cholesterol
Decreases
Triglycerides

Organ system effects

Cardiovascular

Adjunct or alternative for mild dyslipidemia.

Evidence-based benefits

Reduces LDL & TG, raises HDL

Moderate evidence

Potential side effects

Common
    Rare
      Serious

        Drug interactions

        Statins
        Additive — may allow lower dose.
        minor

        Safety & non-supplemental interactions

        Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

        Avoid if you are
        • ·Pregnant or breastfeeding (insufficient safety data)
        • ·Children under 18 (unless directed by a clinician)
        Avoid with these conditions
        • ·Bleeding disorders
        Avoid / monitor with these medications
        • ·Warfarin, DOACs, antiplatelets, NSAIDs (additive bleeding risk)
        Before surgery
        • ·Discuss stopping ≥2 weeks before scheduled surgery.

        Supplement interactions

        Pairs well with

        None listed.

        Avoid combining with

        No specific avoidances listed.

        Dosing & bioavailability

        Typical dose
        500–1500 mg BPF

        Where to buy

        Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

        Herb
        Bergamot Ext…
        Amazon
        Wide selection · fast shipping
        Herb
        Bergamot Ext…
        iHerb
        Global delivery · curated brands
        Herb
        Bergamot Ext…
        Thorne
        Practitioner-grade · NSF tested

        Scientific evidence (8)

        RCTFitoterapia · 2011

        Bergamot polyphenolic fraction on dyslipidemia and metabolic syndrome

        Mollace V, et al.

        30-day RCT of BPF in dyslipidemic patients.

        Key findings

        Significant reductions in LDL-C, triglycerides, and blood glucose.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Bergamot Extract — Reduces LDL & TG, raises HDL

        Live PubMed search

        Live results for "Bergamot Extract Reduces LDL & TG, raises HDL" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Bergamot Extract and "Reduces LDL & TG, raises HDL". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Bergamot Extract — randomized controlled trial

        Live PubMed search

        Live results for "Bergamot Extract randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Bergamot Extract and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Bergamot Extract — meta-analysis

        Live PubMed search

        Live results for "Bergamot Extract meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Bergamot Extract and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Bergamot Extract — pharmacokinetics

        Live PubMed search

        Live results for "Bergamot Extract pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Bergamot Extract and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Bergamot Extract — safety adverse events

        Live PubMed search

        Live results for "Bergamot Extract safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Bergamot Extract and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Bergamot Extract — dose response

        Live PubMed search

        Live results for "Bergamot Extract dose response" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Bergamot Extract and "dose response". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewGoogle Scholar · 1970

        Google Scholar: Bergamot Extract — clinical evidence

        Live Scholar search

        Cross-database citation index for Bergamot Extract as it relates to "clinical evidence".

        Key findings

        Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

        Open study
        Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.