SYS ONLINE
Supplements/Compound

Trans-Resveratrol (Pure)

Purified active isomer of resveratrol.

Buy

Overview

Purified active isomer of resveratrol.

Natural sources
  • Endogenously produced or biosynthesized molecule
  • Standardized pharmaceutical- or food-grade supplement
  • Combined with cofactors that improve absorption or activity
Common forms
  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Forms & variants of Resveratrol

Different chemical forms of Resveratrol behave differently. Browse each form's mechanism, bioavailability, and best-use context.

Mechanism of action

Activates SIRT1 and AMPK; modulates inflammatory pathways.

Pathways
  • · Activates SIRT1
  • · modulates inflammatory pathways

Effects on the body

Supports
endothelial function in T2DM

Organ system effects

Brain & CNS

Trans-Resveratrol (Pure) acts on hallmarks of aging including oxidative stress, mitochondrial dysfunction, and senescence signaling.

Cardiovascular

Trans-Resveratrol (Pure) supports endothelial function, lipid profile, or blood-pressure regulation in cardiovascular trials.

Evidence-based benefits

Improves endothelial function in T2DM

Moderate evidence

Potential side effects

Common
  • · GI upset
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose Trans-Resveratrol (Pure) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Supplement interactions

      Pairs well with
      • NAD+ precursor (NMN or NR)
        Complementary mitochondrial and sirtuin support.
      • Omega-3
        Lowers inflammation and supports membrane integrity.
      • CoQ10
        Supports mitochondrial energetics in cardiac tissue.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      150–500 mg
      Best form
      Most evidence is based on the capsule or softgel form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      With fat

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence8Show studies
      RCTNutr Metab Cardiovasc Dis · 2013

      Resveratrol on FMD in T2DM

      Wong RH, et al.

      Acute crossover in T2DM patients.

      Key findings

      Resveratrol improved flow-mediated dilation dose-dependently.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Trans-Resveratrol (Pure) — Improves endothelial function in T2DM

      Live PubMed search

      Live results for "Trans-Resveratrol (Pure) Improves endothelial function in T2DM" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Trans-Resveratrol (Pure) and "Improves endothelial function in T2DM". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Trans-Resveratrol (Pure) — randomized controlled trial

      Live PubMed search

      Live results for "Trans-Resveratrol (Pure) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Trans-Resveratrol (Pure) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Trans-Resveratrol (Pure) — meta-analysis

      Live PubMed search

      Live results for "Trans-Resveratrol (Pure) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Trans-Resveratrol (Pure) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Trans-Resveratrol (Pure) — pharmacokinetics

      Live PubMed search

      Live results for "Trans-Resveratrol (Pure) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Trans-Resveratrol (Pure) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Trans-Resveratrol (Pure) — safety adverse events

      Live PubMed search

      Live results for "Trans-Resveratrol (Pure) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Trans-Resveratrol (Pure) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Trans-Resveratrol (Pure) — dose response

      Live PubMed search

      Live results for "Trans-Resveratrol (Pure) dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Trans-Resveratrol (Pure) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Trans-Resveratrol (Pure) — clinical evidence

      Live Scholar search

      Cross-database citation index for Trans-Resveratrol (Pure) as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

      Community discussion

      (0 threads)

      Share your experience or read what others have tried. Anecdotes are not medical advice.

      Sign in or create a free account to post or reply.
      Loading discussion…