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evidence · mechanism · dose
Supplements/Compound

Trans-Resveratrol (Pure)

Purified active isomer of resveratrol.

Healthy AgingCardiovascular Health

Overview

Purified active isomer of resveratrol.

Natural sources
    Common forms

      Forms & variants of Resveratrol

      Different chemical forms of Resveratrol behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Resveratrol

      Polyphenol activating sirtuins; bioavailability and clinical effects modest.

      Parent
      Resveratrol

      Polyphenol from grapes — sirtuin activator with mixed human evidence.

      Mechanism of action

      Activates SIRT1 and AMPK; modulates inflammatory pathways.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves endothelial function in T2DM

        Moderate evidence

        Potential side effects

        Common
        • · GI upset
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            150–500 mg
            With food?
            With fat

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
            Trans-Resver…
            Amazon
            Wide selection · fast shipping
            Compound
            Trans-Resver…
            iHerb
            Global delivery · curated brands
            Compound
            Trans-Resver…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTNutr Metab Cardiovasc Dis · 2013

            Resveratrol on FMD in T2DM

            Wong RH, et al.

            Acute crossover in T2DM patients.

            Key findings

            Resveratrol improved flow-mediated dilation dose-dependently.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Trans-Resveratrol (Pure) — Improves endothelial function in T2DM

            Live PubMed search

            Live results for "Trans-Resveratrol (Pure) Improves endothelial function in T2DM" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Trans-Resveratrol (Pure) and "Improves endothelial function in T2DM". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Trans-Resveratrol (Pure) — randomized controlled trial

            Live PubMed search

            Live results for "Trans-Resveratrol (Pure) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Trans-Resveratrol (Pure) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Trans-Resveratrol (Pure) — meta-analysis

            Live PubMed search

            Live results for "Trans-Resveratrol (Pure) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Trans-Resveratrol (Pure) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Trans-Resveratrol (Pure) — pharmacokinetics

            Live PubMed search

            Live results for "Trans-Resveratrol (Pure) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Trans-Resveratrol (Pure) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Trans-Resveratrol (Pure) — safety adverse events

            Live PubMed search

            Live results for "Trans-Resveratrol (Pure) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Trans-Resveratrol (Pure) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Trans-Resveratrol (Pure) — dose response

            Live PubMed search

            Live results for "Trans-Resveratrol (Pure) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Trans-Resveratrol (Pure) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Trans-Resveratrol (Pure) — clinical evidence

            Live Scholar search

            Cross-database citation index for Trans-Resveratrol (Pure) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.