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evidence · mechanism · dose
Supplements/Compound

Resveratrol

Polyphenol activating sirtuins; bioavailability and clinical effects modest.

Healthy AgingCardiovascular Health

Overview

Polyphenol activating sirtuins; bioavailability and clinical effects modest.

Natural sources
  • Red wine
  • Japanese knotweed
  • Berries
Common forms
  • Trans-resveratrol
  • Micronized resveratrol

Forms & variants of Resveratrol

Different chemical forms of Resveratrol behave differently. Browse each form's mechanism, bioavailability, and best-use context.

Trans-form (≥98%)
Trans-Resveratrol (Pure)

Purified active isomer of resveratrol.

Mechanism of action

Activates SIRT1 (debated); modulates AMPK and antioxidant pathways.

Pathways
  • · SIRT1 activation
  • · AMPK

Effects on the body

Supports
Endothelial function

Organ system effects

Cardiovascular

Mild BP reduction in obese/diabetic.

Evidence-based benefits

Mild improvement in endothelial function & insulin sensitivity

Moderate evidence

Potential side effects

Common
  • · GI upset (high dose)
Rare
    Serious

      Drug interactions

      Anticoagulants / CYP3A4 substrates
      Antiplatelet & CYP3A4 inhibition.
      moderate

      Supplement interactions

      Pairs well with
      • Pterostilbene
        More bioavailable analog.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      150–500 mg/d

      Where to buy

      Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Compound
      Resveratrol
      Amazon
      Wide selection · fast shipping
      Compound
      Resveratrol
      iHerb
      Global delivery · curated brands
      Compound
      Resveratrol
      Thorne
      Practitioner-grade · NSF tested

      Scientific evidence (8)

      Meta-analysisAm J Clin Nutr · 2015

      Resveratrol and cardiometabolic outcomes: a meta-analysis

      Liu K, et al.

      Meta-analysis of resveratrol on glucose and lipids.

      Key findings

      Modest improvements in fasting glucose and insulin sensitivity in T2D.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Resveratrol — Mild improvement in endothelial function & insulin sensitivity

      Live PubMed search

      Live results for "Resveratrol Mild improvement in endothelial function & insulin sensitivity" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Resveratrol and "Mild improvement in endothelial function & insulin sensitivity". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Resveratrol — randomized controlled trial

      Live PubMed search

      Live results for "Resveratrol randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Resveratrol and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Resveratrol — meta-analysis

      Live PubMed search

      Live results for "Resveratrol meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Resveratrol and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Resveratrol — pharmacokinetics

      Live PubMed search

      Live results for "Resveratrol pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Resveratrol and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Resveratrol — safety adverse events

      Live PubMed search

      Live results for "Resveratrol safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Resveratrol and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Resveratrol — dose response

      Live PubMed search

      Live results for "Resveratrol dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Resveratrol and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Resveratrol — clinical evidence

      Live Scholar search

      Cross-database citation index for Resveratrol as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.