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evidence · mechanism · dose
Supplements/Herb

Guggul (Commiphora mukul)

Ayurvedic resin used historically for cholesterol and thyroid support.

Thyroid SupportCholesterolCardiovascular Health

Overview

Ayurvedic resin used historically for cholesterol and thyroid support.

Natural sources
    Common forms

      Mechanism of action

      Guggulsterones antagonize the farnesoid X receptor (FXR), altering bile acid/cholesterol metabolism.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Mixed evidence for lipid effects

        Limited evidence

        Possible T3-raising activity

        Limited evidence

        Potential side effects

        Common
        • · Headache
        • · GI upset
        Rare
        • · Rash
        Serious

          Drug interactions

          Statins
          May reduce statin efficacy via FXR.
          moderate

          Safety & non-supplemental interactions

          Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

          Avoid if you are
          • ·Pregnant or breastfeeding (insufficient safety data)
          • ·Children under 18 (unless directed by a clinician)
          Avoid with these conditions
          • ·Bleeding disorders
          Avoid / monitor with these medications
          • ·Warfarin, DOACs, antiplatelets, NSAIDs (additive bleeding risk)
          Before surgery
          • ·Discuss stopping ≥2 weeks before scheduled surgery.

          Supplement interactions

          Pairs well with

          None listed.

          Avoid combining with

          No specific avoidances listed.

          Dosing & bioavailability

          Typical dose
          500–1000 mg standardized to 2.5% guggulsterones
          With food?
          With food

          Where to buy

          Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

          Herb
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          Amazon
          Wide selection · fast shipping
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          iHerb
          Global delivery · curated brands
          Herb
          Guggul (Comm…
          Thorne
          Practitioner-grade · NSF tested

          Scientific evidence (9)

          RCTJAMA · 2003

          Guggul for hyperlipidemia and thyroid function

          Szapary PO, et al.

          8-week RCT of guggul in hyperlipidemia.

          Key findings

          No significant lipid benefit in Western population.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Guggul (Commiphora mukul) — Mixed evidence for lipid effects

          Live PubMed search

          Live results for "Guggul (Commiphora mukul) Mixed evidence for lipid effects" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Guggul (Commiphora mukul) and "Mixed evidence for lipid effects". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Guggul (Commiphora mukul) — Possible T3-raising activity

          Live PubMed search

          Live results for "Guggul (Commiphora mukul) Possible T3-raising activity" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Guggul (Commiphora mukul) and "Possible T3-raising activity". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Guggul (Commiphora mukul) — randomized controlled trial

          Live PubMed search

          Live results for "Guggul (Commiphora mukul) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Guggul (Commiphora mukul) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Guggul (Commiphora mukul) — meta-analysis

          Live PubMed search

          Live results for "Guggul (Commiphora mukul) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Guggul (Commiphora mukul) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Guggul (Commiphora mukul) — pharmacokinetics

          Live PubMed search

          Live results for "Guggul (Commiphora mukul) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Guggul (Commiphora mukul) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Guggul (Commiphora mukul) — safety adverse events

          Live PubMed search

          Live results for "Guggul (Commiphora mukul) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Guggul (Commiphora mukul) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Guggul (Commiphora mukul) — dose response

          Live PubMed search

          Live results for "Guggul (Commiphora mukul) dose response" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Guggul (Commiphora mukul) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewGoogle Scholar · 1970

          Google Scholar: Guggul (Commiphora mukul) — clinical evidence

          Live Scholar search

          Cross-database citation index for Guggul (Commiphora mukul) as it relates to "clinical evidence".

          Key findings

          Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

          Open study
          Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.