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evidence · mechanism · dose
Supplements/Compound

Pterostilbene (Extra)

Methylated resveratrol analog with superior bioavailability.

Healthy AgingCardiovascular Health

Overview

Methylated resveratrol analog with superior bioavailability.

Natural sources
    Common forms

      Forms & variants of Pterostilbene

      Different chemical forms of Pterostilbene behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Pterostilbene

      Bioavailable resveratrol analog with longer half-life.

      Parent
      Pterostilbene

      Methylated analog of resveratrol — better bioavailability and longer half-life.

      Mechanism of action

      Activates Nrf2 and SIRT1; modulates lipid metabolism.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces blood pressure and LDL

        Moderate evidence

        Potential side effects

        Common
          Rare
            Serious

              Drug interactions

              No notable interactions reported.

              Supplement interactions

              Pairs well with

              None listed.

              Avoid combining with

              No specific avoidances listed.

              Dosing & bioavailability

              Typical dose
              100–250 mg
              With food?
              Either

              Where to buy

              Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

              Compound
              Pterostilben…
              Amazon
              Wide selection · fast shipping
              Compound
              Pterostilben…
              iHerb
              Global delivery · curated brands
              Compound
              Pterostilben…
              Thorne
              Practitioner-grade · NSF tested

              Scientific evidence (8)

              RCTJ Toxicol · 2014

              Pterostilbene on BP and lipids

              Riche DM, et al.

              6-8 week DB-RCT in 80 dyslipidemic adults.

              Key findings

              Reduced BP at high dose; mixed lipid effects.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Pterostilbene (Extra) — Reduces blood pressure and LDL

              Live PubMed search

              Live results for "Pterostilbene (Extra) Reduces blood pressure and LDL" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Pterostilbene (Extra) and "Reduces blood pressure and LDL". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Pterostilbene (Extra) — randomized controlled trial

              Live PubMed search

              Live results for "Pterostilbene (Extra) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Pterostilbene (Extra) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Pterostilbene (Extra) — meta-analysis

              Live PubMed search

              Live results for "Pterostilbene (Extra) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Pterostilbene (Extra) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Pterostilbene (Extra) — pharmacokinetics

              Live PubMed search

              Live results for "Pterostilbene (Extra) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Pterostilbene (Extra) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Pterostilbene (Extra) — safety adverse events

              Live PubMed search

              Live results for "Pterostilbene (Extra) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Pterostilbene (Extra) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Pterostilbene (Extra) — dose response

              Live PubMed search

              Live results for "Pterostilbene (Extra) dose response" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Pterostilbene (Extra) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewGoogle Scholar · 1970

              Google Scholar: Pterostilbene (Extra) — clinical evidence

              Live Scholar search

              Cross-database citation index for Pterostilbene (Extra) as it relates to "clinical evidence".

              Key findings

              Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

              Open study
              Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.